Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22281228 | 0.91 | BRD4 (0.39) | P2RX7MAPK1NR3C1NTRK1BRD4 | |
| SCHEMBL22281265 | 0.90 | NTRK1 (0.38) | P2RX7MAPK1NR3C1NTRK1BRD4 | |
| SCHEMBL22280893 | 0.90 | P2RX7 (0.37) | P2RX7MAPK1NR3C1NTRK1BRD4 | |
| SCHEMBL22281264 | 0.88 | BRD4 (0.41) | P2RX7MAPK1NTRK1BRD4CREBBP | |
| SCHEMBL22281230 | 0.88 | NTRK1 (0.41) | P2RX7MAPK1NR3C1NTRK1BRD4 | |
| SCHEMBL22281267 | 0.87 | BRD4 (0.38) | P2RX7MAPK1NR3C1NTRK1BRD4 | |
| SCHEMBL22281262 | 0.86 | NTRK1 (0.40) | P2RX7MAPK1NTRK1BRD4CREBBP | |
| SCHEMBL22281263 | 0.84 | P2RX7 (0.40) | P2RX7MAPK1NTRK1BRD4CREBBP | |
| SCHEMBL20768140 | 0.82 | BRD4 (0.41) | MAPK1NTRK1BRD4CREBBPPDE2A | |
| SCHEMBL19492620 | 0.82 | BRD4 (0.41) | MAPK1NTRK1BRD4CREBBPPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11001590-B2 | Pyrazolopyrimidine derivatives | BAYER ANIMAL HEALTH GMBH (DE) | 2021-05-11 | — | — | US | disclosed |
| US-10934301-B2 | Pyrazolopyrimidine derivatives | BAYER ANIMAL HEALTH GMBH (DE) | 2021-03-02 | — | — | US | disclosed |
| US-20200299299-A1 | NEW PYRAZOLOPYRIMIDINE DERIVATIVES | BAYER ANIMAL HEALTH GMBH (DE) | 2020-09-24 | — | — | US | disclosed |
| US-20200239482-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES | BAYER ANIMAL HEALTH GMBH (DE) | 2020-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11001590-B2 | Pyrazolopyrimidine derivatives | P2RX5, RECQL, P2RX1 | P2RX7 8/4885MAPK1 3964/4885NR3C1 3494/4885 |
| US-20200239482-A1 | PYRAZOLOPYRIMIDINE DERIVATIVES | P2RX5, RECQL, P2RX1 | P2RX7 8/4885MAPK1 3964/4885NR3C1 3494/4885 |
| US-10934301-B2 | Pyrazolopyrimidine derivatives | P2RX5, RECQL, P2RX1 | P2RX7 8/4885MAPK1 3964/4885NR3C1 3494/4885 |
| US-20200299299-A1 | NEW PYRAZOLOPYRIMIDINE DERIVATIVES | P2RX5, RECQL, P2RX1 | P2RX7 8/4885MAPK1 3487/4885NR3C1 4133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.