Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 9/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.33 |
| ▸ | CDC25B | P30305 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20692248 | 0.80 | NLRP3 (0.44) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL19505705 | 0.80 | NLRP3 (0.46) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL26590829 | 0.78 | NLRP3 (0.45) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL22280260 | 0.77 | MEN1 (0.41) | NLRP3MAOAMAOBPRKCIMEN1 | |
| SCHEMBL22013010 | 0.77 | NLRP3 (0.43) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL19476121 | 0.76 | NLRP3 (0.42) | NLRP3MEN1KMT2AATMSMN1; SMN2 | |
| SCHEMBL18007624 | 0.74 | MEN1 (0.41) | NLRP3MAOAMAOBPRKCIMEN1 | |
| SCHEMBL18393609 | 0.74 | MAPK1 (0.41) | NLRP3MAOAMAOBPRKCIMEN1 | |
| SCHEMBL22011681 | 0.74 | MEN1 (0.41) | NLRP3MAOAMAOBPRKCIMEN1 | |
| SCHEMBL24294871 | 0.73 | MEN1 (0.38) | NLRP3MAOAMAOBPRKCIMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020154499-A1 | SULFONIMIDAMIDE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-07-30 | — | — | WO | disclosed |