Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 16/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20692248 | 0.80 | NLRP3 (0.44) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL19505705 | 0.80 | NLRP3 (0.46) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL21962723 | 0.80 | NLRP3 (0.47) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL22012974 | 0.78 | NLRP3 (0.46) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL26590829 | 0.78 | NLRP3 (0.45) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL20691958 | 0.77 | BRD4 (0.37) | NLRP3SMN1; SMN2ALDH1A1 | |
| SCHEMBL22282131 | 0.77 | NLRP3 (0.40) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL19476121 | 0.76 | NLRP3 (0.42) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL30244294 | 0.74 | CASP1 (0.35) | NLRP3SMN1; SMN2ALDH1A1 | |
| SCHEMBL18007595 | 0.74 | CASP1 (0.35) | NLRP3SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |