Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 3/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20527122 | 0.75 | CYP11B2 (0.48) | CYP11B2CYP11B1PDE3BPDE3AGABRA5 | |
| SCHEMBL18227002 | 0.75 | CYP11B2 (0.48) | CYP11B2CYP11B1PDE3BPDE3AGABRA5 | |
| Hydrochloric Acid SCHEMBL18226990 | 0.74 | CYP11B2 (0.47) | CYP11B2CYP11B1PDE3BPDE3AGABRA5 | |
| SCHEMBL474484 | 0.72 | CYP11B1 (0.51) | CYP11B2CYP11B1PDE3BPDE3AHTR1A | |
| SCHEMBL9411106 | 0.70 | CYP11B2 (0.53) | CYP11B2CYP11B1PDE3BPDE3AGABRA5 | |
| SCHEMBL3347754 | 0.69 | PDE3B (0.44) | CYP11B2CYP11B1PDE3BPDE3AGABRA5 | |
| SCHEMBL280110 | 0.68 | TSHR (0.58) | PDE3BPDE3A | |
| SCHEMBL5985192 | 0.68 | CYP11B2 (0.55) | CYP11B2CYP11B1PDE3BPDE3AGABRA5 | |
| SCHEMBL19153823 | 0.67 | ACVRL1 (0.39) | — | |
| SCHEMBL12101220 | 0.67 | CYP11B2 (0.53) | CYP11B2CYP11B1PDE3BPDE3AGABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519526-A1 | TRICYCLIC COMPOUNDS FOR USE AS KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080510-A1 | TRICYCLIC COMPOUNDS FOR USE AS KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2011-07-07 | — | — | WO | disclosed |