Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10330507 | 0.90 | KMT2A (0.59) | KMT2ATP53TSHRMAPK1HSP90AA1 | |
| SCHEMBL10330500 | 0.88 | KMT2A (0.58) | KMT2ATP53TSHRMAPK1HSP90AA1 | |
| SCHEMBL10269519 | 0.86 | KMT2A (0.63) | KMT2ATP53TSHRMAPK1HPGD | |
| SCHEMBL15343524 | 0.85 | KMT2A (0.67) | KMT2ATP53TSHRMAPK1HSP90AA1 | |
| SCHEMBL14454157 | 0.84 | KMT2A (0.61) | KMT2ATP53TSHRMAPK1HSP90AA1 | |
| SCHEMBL15108850 | 0.84 | KMT2A (0.61) | KMT2ATP53TSHRMAPK1HSP90AA1 | |
| SCHEMBL10330501 | 0.84 | TP53 (0.79) | KMT2ATP53TSHRMAPK1ERCC5 | |
| SCHEMBL4559654 | 0.83 | KMT2A (0.49) | KMT2ATP53TSHRMAPK1HSP90AA1 | |
| SCHEMBL30514751 | 0.83 | KMT2A (0.59) | KMT2ATP53TSHRMAPK1HPGD | |
| SCHEMBL5127220 | 0.82 | TP53 (0.59) | KMT2ATP53TSHRHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668154-B1 | FORMULATION COMPONENT | SYNGENTA LTD (GB) | 2018-03-21 | — | — | EP | disclosed |
| US-20160113271-A1 | FORMULATION COMPONENT | SYNGENTA LIMITED (GB) | 2016-04-28 | — | — | US | disclosed |
| US-20160113271-A1 | FORMULATION COMPONENT | SYNGENTA LIMITED (GB) | 2016-04-28 | — | — | US | disclosed |
| US-8735384-B2 | Amino heteroaryl compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2014-05-27 | — | — | US | disclosed |
| US-20140051580-A1 | FORMULATION COMPONENT | SYNGENTA LIMITED (GB) | 2014-02-20 | — | — | US | disclosed |
| US-20140051580-A1 | FORMULATION COMPONENT | SYNGENTA LIMITED (GB) | 2014-02-20 | — | — | US | disclosed |
| US-20130040931-A1 | Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use | AMGEN INC. (US) | 2013-02-14 | — | — | US | disclosed |
| US-20120184438-A1 | FORMULATIONS | SYNGENTA CROP PROTECTION, LLC (US) | 2012-07-19 | — | — | US | disclosed |
| US-20120184438-A1 | FORMULATIONS | SYNGENTA CROP PROTECTION, LLC (US) | 2012-07-19 | — | — | US | disclosed |
| WO-2011090911-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-07-28 | — | — | WO | disclosed |
| WO-2011010082-A2 | FORMULATIONS | SYNGENTA LIMITED (GB) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040931-A1 | Amino Heteroaryl Compounds as Beta-Secretase Modulators and Methods of Use | BACE1, BACE2, APH1B | KMT2A 1229/4885TP53 2506/4885TSHR 3909/4885 |
| US-20160113271-A1 | FORMULATION COMPONENT | BCHE, HRH4, TBCB | KMT2A 1326/4885TP53 2231/4885TSHR 3646/4885 |
| US-20120184438-A1 | FORMULATIONS | CBR3, H1-5, H1-0 | KMT2A 460/4885TP53 3812/4885TSHR 1688/4885 |
| US-20140051580-A1 | FORMULATION COMPONENT | BCHE, HRH4, TBCB | KMT2A 1326/4885TP53 2231/4885TSHR 3646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.