Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 16/20 | 0.54 |
| ▸ | MAPK3 | P27361 | 7/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20931754 | 1.00 | MAPK1 (0.54) | MAPK1MAPK3LRRK2ROCK1ROCK2 | |
| SCHEMBL20931683 | 0.92 | MAPK1 (0.55) | MAPK1MAPK3LRRK2ROCK1ROCK2 | |
| SCHEMBL22284173 | 0.92 | MAPK1 (0.55) | MAPK1MAPK3LRRK2ROCK1ROCK2 | |
| SCHEMBL30554358 | 0.92 | MAPK1 (0.55) | MAPK1MAPK3LRRK2ROCK1ROCK2 | |
| SCHEMBL30554347 | 0.91 | MAPK1 (0.53) | MAPK1MAPK3ROCK1ROCK2PRKG1 | |
| SCHEMBL20916811 | 0.91 | MAPK1 (0.53) | MAPK1MAPK3ROCK1ROCK2PRKG1 | |
| SCHEMBL30554352 | 0.91 | MAPK1 (0.53) | MAPK1MAPK3ROCK1ROCK2PRKG1 | |
| SCHEMBL20931371 | 0.91 | MAPK1 (0.53) | MAPK1MAPK3ROCK1ROCK2PRKG1 | |
| SCHEMBL20916856 | 0.91 | MAPK1 (0.53) | MAPK1MAPK3ROCK1ROCK2PRKG1 | |
| SCHEMBL20931474 | 0.90 | MAPK1 (0.54) | MAPK1MAPK3LRRK2ROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020200161-A1 | SALT OF INDAZOLYL-CONTAINING TRICYCLIC DERIVATIVE AND CRYSTAL FORM THEREOF | 上海翰森生物医药科技有限公司 | 2020-10-08 | — | — | WO | disclosed |
| EP-3699179-A1 | PYRAZOLYL-CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. (CN) | 2020-08-26 | — | — | EP | disclosed |
| US-20200247815-A1 | PYRAZOLYL-CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI HANSOH BIOMEDICAL CO., LTD. (CN) | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247815-A1 | PYRAZOLYL-CONTAINING TRICYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | MAPK1, MAPK11, MAPK14 | MAPK1 1/4885MAPK3 14/4885LRRK2 2759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.