Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16653971 | 0.93 | OPRK1 (0.45) | TSHRMEN1KMT2AALDH1A1OPRM1 | |
| SCHEMBL9052715 | 0.90 | HTT (0.47) | HTTTSHRHSD17B10MEN1KMT2A | |
| SCHEMBL725217 | 0.85 | ALDH1A1 (0.53) | HTTTSHRHSD17B10MEN1KMT2A | |
| SCHEMBL17941715 | 0.85 | ALDH1A1 (0.53) | HTTTSHRHSD17B10MEN1KMT2A | |
| SCHEMBL2310169 | 0.85 | TSHR (0.51) | TSHRMEN1KMT2AALDH1A1GAA | |
| SCHEMBL3508595 | 0.85 | ALDH1A1 (0.53) | HTTTSHRHSD17B10MEN1KMT2A | |
| SCHEMBL79747 | 0.84 | HTT (0.62) | HTTTSHRHSD17B10MEN1KMT2A | |
| Alcohol SCHEMBL2794145 | 0.82 | TSHR (0.58) | HTTTSHRHSD17B10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2313460 | 0.82 | HTT (0.61) | HTTTSHRHSD17B10MEN1KMT2A | |
| SCHEMBL9320386 | 0.82 | HTT (0.66) | HTTTSHRHSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011090911-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-07-28 | — | — | WO | disclosed |