Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.67 |
| ▸ | STAT3 | P40763 | 1/20 | 0.67 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11485891 | 0.80 | KDM4E (0.71) | KDM4ESTAT3HIF1ANPC1RAB9A | |
| SCHEMBL25380488 | 0.80 | KDM4E (0.71) | KDM4ESTAT3HIF1ANPC1RAB9A | |
| SCHEMBL29805260 | 0.80 | KDM4E (1.00) | KDM4ESTAT3HIF1ANPC1RAB9A | |
| SCHEMBL498053 | 0.80 | KDM4E (1.00) | KDM4ESTAT3HIF1ANPC1RAB9A | |
| SCHEMBL22284877 | 0.78 | KDM4E (0.62) | KDM4ESTAT3HIF1ANPC1RAB9A | |
| SCHEMBL967165 | 0.78 | KDM4E (0.62) | KDM4ESTAT3HIF1ANPC1RAB9A | |
| SCHEMBL6530251 | 0.77 | NPC1 (0.68) | KDM4ESTAT3HIF1ANPC1RAB9A | |
| SCHEMBL7668372 | 0.77 | KDM4E (0.66) | KDM4ESTAT3HIF1ANPC1RAB9A | |
| SCHEMBL31148407 | 0.77 | KDM4E (0.66) | KDM4ESTAT3HIF1ANPC1RAB9A | |
| SCHEMBL5435670 | 0.76 | KDM4E (0.69) | KDM4ESTAT3HIF1ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940833-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF | Memory Pharmaceuticals Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007038367-A1 | INDAZOLES, BENZOTHIAZOLES, BENZOISOTHIAZOLES, BENZISOXAZOLES, PYRAZOLOPYRIDINES, ISOTHIAZOLOPYRIDINES, AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICALS CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |
| CN-1189460-C | New method of preparing Granisetron intermediate | NINGBO TIANHENG PHARMACRUTICAL (CN) | 2005-02-16 | — | — | CN | disclosed |