Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 16/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 16/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2228553 | 1.00 | SLC6A2 (0.39) | SLC6A2SLC6A3SLC6A4KDM1ARCOR1 | |
| SCHEMBL2225309 | 1.00 | SLC6A2 (0.39) | SLC6A2SLC6A3SLC6A4KDM1ARCOR1 | |
| SCHEMBL2226673 | 0.90 | SLC6A2 (0.41) | SLC6A2SLC6A3SLC6A4KDM1ARCOR1 | |
| SCHEMBL2228602 | 0.90 | SLC6A2 (0.41) | SLC6A2SLC6A3SLC6A4KDM1ARCOR1 | |
| SCHEMBL2784188 | 0.88 | SLC6A2 (0.39) | SLC6A2SLC6A3SLC6A4CYP2D6KCNH2 | |
| SCHEMBL2225021 | 0.86 | KDM1A (0.52) | SLC6A2SLC6A3SLC6A4KDM1ARCOR1 | |
| SCHEMBL1421527 | 0.86 | KDM1A (0.52) | SLC6A2SLC6A3SLC6A4KDM1ARCOR1 | |
| SCHEMBL3634310 | 0.84 | MAOA (0.47) | KDM1ARCOR1 | |
| SCHEMBL2352598 | 0.81 | KDM1A (0.52) | SLC6A2SLC6A3SLC6A4KDM1ARCOR1 | |
| SCHEMBL2228338 | 0.81 | KDM1A (0.52) | SLC6A2SLC6A3SLC6A4KDM1ARCOR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513052-A1 | PYRROLIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011085886-A1 | PYRROLIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |