Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14922272 | 0.86 | CHKA (0.54) | CHKAKMT2AKDM4ENPC1RAB9A | |
| SCHEMBL30760572 | 0.83 | KDM4E (0.50) | KMT2AKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10061499 | 0.82 | KDM4E (0.61) | CHKAKMT2AKDM4ENPC1RAB9A | |
| SCHEMBL29126327 | 0.82 | CHKA (0.50) | CHKAKMT2AKDM4ENPC1RAB9A | |
| SCHEMBL11245265 | 0.79 | DRD4 (0.57) | CHKAKMT2AKDM4ENPC1RAB9A | |
| SCHEMBL14922279 | 0.79 | CHKA (0.50) | CHKAKMT2AKDM4ENPC1RAB9A | |
| SCHEMBL8320347 | 0.78 | ADRB1 (0.63) | KMT2AKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27313475 | 0.78 | KDM4E (0.40) | CHKAKMT2AKDM4ENPC1RAB9A | |
| SCHEMBL1599368 | 0.77 | SIRT6 (0.58) | CHKAKMT2AKDM4ENPC1RAB9A | |
| SCHEMBL22634636 | 0.76 | SIRT6 (0.68) | MAPTMAPK1ALDH1A1SIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519517-A2 | TYPE II RAF KINASE INHIBITORS | Dana-Farber Cancer Institute, Inc. (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011090738-A2 | TYPE II RAF KINASE INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2011-07-28 | — | — | WO | disclosed |