Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 9/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.45 |
| ▸ | PDE4A | P27815 | 4/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.45 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.43 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22288916 | 0.91 | GPR119 (0.53) | PDE3BPDE3AGPR119ALDH3A1ALDH1A3 | |
| SCHEMBL22288557 | 0.86 | PDE3B (0.52) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL22317772 | 0.83 | PDE3B (0.60) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL22317768 | 0.83 | PDE3B (0.60) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL16156958 | 0.79 | PDE3B (0.78) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL10703474 | 0.76 | PDE3B (0.55) | PDE3BPDE3AGPR119ALDH3A1ALDH1A3 | |
| SCHEMBL22288535 | 0.76 | PDE3B (0.52) | PDE3BPDE3AGPR119 | |
| SCHEMBL22317770 | 0.76 | PDE3B (0.52) | PDE3BPDE3AGPR119 | |
| SCHEMBL17446946 | 0.74 | PDE3B (0.58) | PDE3BPDE3AGPR119ALDH3A1ALDH1A3 | |
| SCHEMBL22317555 | 0.74 | PDE3B (0.47) | PDE3BPDE3AALDH3A1ALDH1A3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020157199-A1 | ANNULATED DIHYDROPYRIDAZINONE COMPOUNDS AS ANTI-CANCER COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | WO | claimed |
| WO-2020157199-A1 | ANNULATED DIHYDROPYRIDAZINONE COMPOUNDS AS ANTI-CANCER COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020157199-A1 | ANNULATED DIHYDROPYRIDAZINONE COMPOUNDS AS ANTI-CANCER COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | WO | disclosed |