Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 12/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.47 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.41 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10955592 | 0.77 | PDE3B (0.52) | PDE3BPDE3AALDH3A1ALDH1A3GAA | |
| SCHEMBL22288916 | 0.74 | GPR119 (0.53) | PDE3BPDE3AALDH3A1ALDH1A3GAA | |
| SCHEMBL22288560 | 0.74 | PDE3B (0.50) | PDE3BPDE3AALDH3A1ALDH1A3GAA | |
| SCHEMBL16156958 | 0.70 | PDE3B (0.78) | PDE3BPDE3A | |
| SCHEMBL10703474 | 0.67 | PDE3B (0.55) | PDE3BPDE3AALDH3A1ALDH1A3 | |
| SCHEMBL10757481 | 0.65 | PDE3B (0.52) | PDE3BPDE3ASMN1; SMN2 | |
| SCHEMBL17446946 | 0.65 | PDE3B (0.58) | PDE3BPDE3AALDH3A1ALDH1A3GAA | |
| SCHEMBL10763921 | 0.65 | PDE3B (0.71) | PDE3BPDE3A | |
| SCHEMBL10764706 | 0.65 | PDE3B (0.57) | PDE3BPDE3A | |
| SCHEMBL20703131 | 0.65 | PDE3B (0.69) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020157199-A1 | ANNULATED DIHYDROPYRIDAZINONE COMPOUNDS AS ANTI-CANCER COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | WO | disclosed |