Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALPG | P10696 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | OGG1 | O15527 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26124336 | 0.79 | KDM4E (0.45) | KDM4EALDH1A1LMNAMAPTL3MBTL1 | |
| SCHEMBL22304671 | 0.79 | ALDH1A1 (0.39) | KDM4EALDH1A1MAPTHTTHDAC6 | |
| SCHEMBL487554 | 0.78 | HCAR2 (0.47) | KDM4EALDH1A1LMNAPOLBHTT | |
| SCHEMBL31259721 | 0.77 | KDM4E (0.54) | KDM4EALDH1A1LMNAMAPTL3MBTL1 | |
| SCHEMBL31259712 | 0.77 | KDM4E (0.54) | KDM4EALDH1A1LMNAMAPTL3MBTL1 | |
| SCHEMBL29779593 | 0.76 | MAPK1 (0.46) | KDM4EALDH1A1LMNAMAPTL3MBTL1 | |
| SCHEMBL19689562 | 0.76 | MAPK1 (0.46) | KDM4EALDH1A1LMNAMAPTL3MBTL1 | |
| SCHEMBL27026775 | 0.76 | KDM4E (0.55) | KDM4EALDH1A1LMNAMAPTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL27007918 | 0.74 | KDM4E (0.53) | KDM4EALDH1A1LMNAMAPTL3MBTL1 | |
| SCHEMBL18339782 | 0.72 | SMN1; SMN2 (0.38) | KDM4EALDH1A1POLBHTTHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020157201-A1 | OXADIAZINONE COMPOUNDS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020157201-A1 | OXADIAZINONE COMPOUNDS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | WO | disclosed |