Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 13/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12802905 | 1.00 | CHRM1 (0.53) | CHRM1KCNH2CNR1CHRNB2CHRNA7 | |
| SCHEMBL12802717 | 0.89 | CHRM1 (0.57) | CHRM1ADAM17 | |
| SCHEMBL17656794 | 0.88 | CHRNB2 (0.44) | CHRM1KCNH2CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL6891970 | 0.87 | GAA (0.49) | CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL2275863 | 0.87 | CHRM1 (0.70) | CHRM1KCNH2ADAM17 | |
| SCHEMBL12803202 | 0.86 | CHRM1 (0.58) | CHRM1 | |
| SCHEMBL12958957 | 0.86 | CHRM1 (0.58) | CHRM1 | |
| SCHEMBL12803777 | 0.86 | CHRM1 (0.46) | CHRM1CNR1 | |
| SCHEMBL12802941 | 0.85 | CHRM1 (0.70) | CHRM1KCNH2 | |
| SCHEMBL2221937 | 0.85 | CHRM1 (0.70) | CHRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512243-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |