Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12802905 | 0.87 | CHRM1 (0.53) | CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL2228996 | 0.87 | CHRM1 (0.53) | CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL6892450 | 0.86 | CHRM1 (0.54) | GAAKMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL17656794 | 0.85 | CHRNB2 (0.44) | MAPTCHRNB2CHRNA7CHRNA4POLB | |
| SCHEMBL2224496 | 0.84 | GAA (0.55) | GAAKMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6892258 | 0.83 | GAA (0.56) | GAAKMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6891717 | 0.83 | CHRM1 (0.54) | GAAKMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6893880 | 0.83 | CHRM1 (0.54) | GAAKMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL19932550 | 0.83 | CHRM1 (0.57) | — | |
| SCHEMBL6890001 | 0.82 | SMN1; SMN2 (0.51) | GAAKMT2ALMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2512243-B1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2016-04-06 | — | — | EP | disclosed |
| WO-2011084368-A1 | QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |