Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.44 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.44 |
| ▸ | MRE11 | P49959 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22290471 | 0.91 | GPR142 (0.46) | GPR142ROCK1ROCK2MRE11PARP1 | |
| SCHEMBL22306709 | 0.91 | HDAC4 (0.46) | GPR142HDAC4MEF2DEP300ROCK1 | |
| SCHEMBL30315834 | 0.91 | HDAC4 (0.46) | GPR142HDAC4MEF2DEP300ROCK1 | |
| SCHEMBL22290342 | 0.87 | ROCK1 (0.52) | GPR142HDAC4MEF2DEP300ROCK1 | |
| SCHEMBL28681782 | 0.86 | MRE11 (0.42) | GPR142HDAC4MEF2DEP300ROCK1 | |
| SCHEMBL22290702 | 0.84 | ROCK1 (0.57) | GPR142ROCK1ROCK2MRE11PARP1 | |
| SCHEMBL22290476 | 0.84 | MRE11 (0.49) | GPR142ROCK1ROCK2MRE11PARP1 | |
| SCHEMBL22306526 | 0.82 | HDAC3 (0.47) | GPR142HDAC4MEF2DEP300ROCK1 | |
| SCHEMBL30315814 | 0.82 | HDAC3 (0.47) | GPR142HDAC4MEF2DEP300ROCK1 | |
| SCHEMBL22290311 | 0.82 | ROCK1 (0.50) | GPR142HDAC4MEF2DEP300ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230079819-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-03-16 | — | — | US | disclosed |
| EP-3917527-A1 | COMPOUNDS AND USES THEREOF | Foghorn Therapeutics Inc. (US) | 2021-12-08 | — | — | EP | disclosed |
| WO-2020160180-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230079819-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | GPR142 4722/4885HDAC4 152/4885MEF2D 3791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.