SCHEMBL22294366

SCHEMBL22294366

COC(=O)Nc1ccc2c(c1)NC(=O)C/C=C/C[C@H](N)c1nc-2c[nH]1

nearest known ligand 0.49

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
F11 P03951 20/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23049484 0.91 F11 (0.51) F11
SCHEMBL22294449 0.91 F11 (0.51) F11
SCHEMBL18059787 0.91 F11 (0.51) F11
SCHEMBL18059790 0.91 F11 (0.51) F11
SCHEMBL22294391 0.88 F11 (0.44) F11
SCHEMBL22294380 0.88 F11 (0.42) F11
SCHEMBL23049459 0.88 F11 (0.42) F11
SCHEMBL22294632 0.88 F11 (0.52) F11
SCHEMBL23049358 0.88 F11 (0.52) F11
SCHEMBL22294630 0.88 F11 (0.52) F11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2534154-B1 MACROCYCLES AS FACTOR XIA INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2020-08-05 EP disclosed