Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 20/20 | 0.51 |
| ▸ | F7 | P08709 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23049484 | 1.00 | F11 (0.51) | F11F7F10PRSS1PRSS2 | |
| SCHEMBL18059787 | 1.00 | F11 (0.51) | F11F7F10PRSS1PRSS2 | |
| SCHEMBL18059790 | 1.00 | F11 (0.51) | F11F7F10PRSS1PRSS2 | |
| SCHEMBL22294366 | 0.91 | F11 (0.49) | F11 | |
| SCHEMBL23049480 | 0.88 | F11 (0.39) | F11F7F10PRSS1PRSS2 | |
| SCHEMBL23049345 | 0.88 | F11 (0.39) | F11F7F10PRSS1PRSS2 | |
| SCHEMBL23049416 | 0.87 | F11 (0.42) | F11 | |
| SCHEMBL22294391 | 0.87 | F11 (0.44) | F11 | |
| SCHEMBL23049423 | 0.87 | F11 (0.42) | F11 | |
| SCHEMBL23049415 | 0.87 | F11 (0.42) | F11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3786165-A1 | SYNTHETIC INTERMEDIATES FOR PRODUCING MACROCYCLES AS FACTOR XIA INHIBITORS | Bristol-Myers Squibb Company (US) | 2021-03-03 | — | — | EP | disclosed |
| EP-2534154-B1 | MACROCYCLES AS FACTOR XIA INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2020-08-05 | — | — | EP | disclosed |