Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 14/20 | 0.46 |
| ▸ | HSD11B2 | P80365 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL231374 | 0.92 | HSD11B1 (0.55) | HSD11B1HSD11B2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL2229543 | 0.83 | HSD11B1 (0.51) | HSD11B1HSD11B2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL2830112 | 0.78 | HSD11B1 (0.75) | HSD11B1HSD11B2 | |
| SCHEMBL230350 | 0.78 | LMNA (0.45) | HSD11B1HSD11B2 | |
| SCHEMBL231799 | 0.77 | HSD11B1 (0.46) | HSD11B1HSD11B2 | |
| SCHEMBL231962 | 0.76 | HSD11B1 (0.72) | HSD11B1HSD11B2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL233012 | 0.76 | HSD11B1 (0.46) | HSD11B1HSD11B2 | |
| SCHEMBL231373 | 0.75 | HSD11B1 (0.60) | HSD11B1HSD11B2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL2831645 | 0.75 | HSD11B1 (0.64) | HSD11B1HSD11B2 | |
| SCHEMBL16588910 | 0.74 | HSD11B1 (0.58) | HSD11B1HSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2345640-A1 | Adamantyl- acetamide derivatives as inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme | Abbott Laboratories (US) | 2011-07-20 | — | — | EP | disclosed |