Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 10/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.52 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.52 |
| ▸ | CHRNG | P07510 | 4/20 | 0.52 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.52 |
| ▸ | CHRND | Q07001 | 4/20 | 0.52 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22296208 | 0.81 | CHRM4 (0.39) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL30116323 | 0.78 | HRH3 (0.57) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL20388854 | 0.78 | HRH3 (0.57) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL4719579 | 0.76 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL4881480 | 0.76 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL22296233 | 0.76 | CCR6 (0.36) | HRH3 | |
| SCHEMBL24746187 | 0.75 | PIK3CA (0.37) | CHRNB2CHRNA4HRH3 | |
| SCHEMBL23865949 | 0.75 | EGFR (0.36) | CHRNB2CHRNA4CHRNB4CHRNA3HRH3 | |
| SCHEMBL24747235 | 0.75 | PIK3CA (0.37) | CHRNB2CHRNA4HRH3 | |
| SCHEMBL17055343 | 0.75 | PIK3CA (0.37) | CHRNB2CHRNA4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689871-A1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2020-08-05 | — | — | EP | disclosed |