Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 10/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.40 |
| ▸ | BTK | Q06187 | 9/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22296218 | 0.86 | JAK3 (0.47) | JAK3JAK1BTKEGFR | |
| SCHEMBL22296380 | 0.86 | JAK3 (0.47) | JAK3JAK1BTKEGFR | |
| SCHEMBL22222692 | 0.83 | JAK3 (0.41) | JAK3JAK1BTKEGFRJAK2 | |
| SCHEMBL22296219 | 0.82 | JAK3 (0.51) | JAK3JAK1BTKEGFR | |
| SCHEMBL22296385 | 0.82 | JAK3 (0.51) | JAK3JAK1BTKEGFR | |
| SCHEMBL22296379 | 0.82 | JAK3 (0.51) | JAK3JAK1BTKEGFR | |
| SCHEMBL22222627 | 0.79 | JAK3 (0.43) | JAK3JAK1BTKEGFR | |
| SCHEMBL16285113 | 0.78 | JAK3 (0.42) | JAK3JAK1BTKJAK2TEAD1 | |
| SCHEMBL23328302 | 0.78 | JAK3 (0.42) | JAK3JAK1BTKEGFR | |
| SCHEMBL22222678 | 0.78 | JAK3 (0.47) | JAK3JAK1BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689871-B1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | SHANGHAI HAIYAN PHARMACEUTICAL TECH CO LTD (CN) | 2021-09-29 | — | — | EP | disclosed |
| EP-3689871-A1 | 4,6,7-TRISUBSTITUTED 1,2-DIHYDROPYRROL[3,4-C]PYRIDIN/PYRIMIDIN-3-ONE DERIVATIVE AND USE | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. (CN) | 2020-08-05 | — | — | EP | disclosed |