Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28727117 | 1.00 | ACE (0.58) | ACEATMPOLBPIN1TDP1 | |
| SCHEMBL4461003 | 0.84 | ACE (0.59) | ACEPOLBPIN1TDP1APEX1 | |
| SCHEMBL2229670 | 0.84 | ACE (0.59) | ACEPOLBPIN1TDP1APEX1 | |
| SCHEMBL4454388 | 0.84 | ACE (0.59) | ACEPOLBPIN1TDP1APEX1 | |
| SCHEMBL29624413 | 0.78 | MMP2 (0.42) | ACEPIN1TSHR | |
| SCHEMBL14770233 | 0.77 | — | — | |
| SCHEMBL12798692 | 0.77 | — | — | |
| SCHEMBL6792627 | 0.76 | ACE (0.75) | ACE | |
| SCHEMBL6792635 | 0.76 | ACE (0.75) | ACE | |
| SCHEMBL4885276 | 0.76 | ACE (0.51) | ACEITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114456101-A | Synthesis method of key intermediate for synthesizing PF-07321332 | 上海璨谊生物科技有限公司 | 2022-05-10 | — | — | CN | disclosed |
| EP-1909814-B1 | Peptides for induction and enhancement of apoptosis in tumor cells | GEORG AUGUST UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTS OHNE BEREICH HUMANMEDIZIN (DE) | 2015-06-24 | — | — | EP | disclosed |
| US-8334258-B2 | Administering gonadotropin-hormone-releasing hormone (GnRH) antagonist peptide for inducing/enhancing apoptosis of breast cancer or malignant melanoma or gynaecological cancer | GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN STIFTUNG ÖFFENTLICHEN RECHTS (UNIVERSITÄTSMEDIZIN) (DE) | 2012-12-18 | — | — | US | disclosed |
| US-20120004182-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR INDUCTION AND ENHANCEMENT OF APOPTOSIS IN TUMOR CELLS | GEORG-AUGUST-UNIVERSITAET GOETTINGEN STIFTUNG OEFFENTLICHEN RECHTS, UNIVERSITAETSMEDIZIN (DE) | 2012-01-05 | — | — | US | disclosed |
| WO-2012001149-A2 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR INDUCTION AND ENHANCEMENT OF APOPTOSIS IN TUMOR CELLS | GEORG-AUGUST-UNIVERSITÄT GÖTTINGEN (DE) | 2012-01-05 | — | — | WO | disclosed |
| US-20080167250-A1 | Method For Induction and Enhancement of Apoptosis In Tumor Cells | GEORG-AUGUST-UNIVERSITAET GOETTINGEN, STIFTUNG OEFFENTLECHEN RECHTS, BEREICH HUMANMEDIZIN (DE) | 2008-07-10 | — | — | US | disclosed |
| EP-1909814-A1 | METHOD FOR INDUCTION AND ENHANCEMENT OF APOPTOSIS IN TUMOR CELLS | Georg-August-Universität Göttingen Stiftung des Öffentlichen Rechts (Bereich Humanmedizin) (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007012430-A1 | METHOD FOR INDUCTION AND ENHANCEMENT OF APOPTOSIS IN TUMOR CELLS | GEORG-AUGUST-UNIVERSITÄT-GÖTTINGEN (DE) | 2007-02-01 | — | — | WO | disclosed |
| EP-0942754-B1 | CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER | MERCK & CO INC (US) | 2003-05-07 | — | — | EP | disclosed |