Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.51 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.34 |
| ▸ | ITGAL | P20701 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5127864 | 1.00 | ACE (0.51) | ACEITGB2ICAM1ITGALBTK | |
| SCHEMBL2229670 | 0.78 | ACE (0.59) | ACEITGB2ICAM1ITGAL | |
| SCHEMBL4461003 | 0.78 | ACE (0.59) | ACEITGB2ICAM1ITGAL | |
| SCHEMBL4454388 | 0.78 | ACE (0.59) | ACEITGB2ICAM1ITGAL | |
| SCHEMBL28727117 | 0.76 | ACE (0.58) | ACEITGB2ICAM1ITGAL | |
| SCHEMBL6792627 | 0.70 | ACE (0.75) | ACE | |
| SCHEMBL6792635 | 0.70 | ACE (0.75) | ACE | |
| SCHEMBL12798692 | 0.67 | — | — | |
| SCHEMBL14770233 | 0.67 | — | — | |
| SCHEMBL25175295 | 0.67 | ACE (0.47) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008525522-A | — | — | 2008-07-17 | — | — | JP | claimed |
| EP-1844022-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | Hanmi Pharm. Co., Ltd. (KR) | 2007-10-17 | — | — | EP | claimed |
| WO-2006071017-A1 | QUINAZOLINE DERIVATIVES FOR INHIBITING CANCER CELL GROWTH AND METHOD FOR THE PREPARATION THEREOF | HANMI PHARM. CO., LTD. (KR) | 2006-07-06 | — | — | WO | claimed |