Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CES2 | O00748 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.41 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20548046 | 1.00 | EPHX1 (0.71) | EPHX1HTTMEN1THRBKMT2A | |
| SCHEMBL15279667 | 1.00 | EPHX1 (0.71) | EPHX1HTTMEN1THRBKMT2A | |
| SCHEMBL722968 | 1.00 | EPHX1 (0.71) | EPHX1HTTMEN1THRBKMT2A | |
| SCHEMBL8979926 | 0.98 | EPHX1 (0.67) | EPHX1HTTMEN1THRBKMT2A | |
| SCHEMBL23342876 | 0.95 | EPHX1 (0.64) | EPHX1HTTMEN1THRBKMT2A | |
| SCHEMBL8979942 | 0.95 | EPHX1 (0.64) | EPHX1HTTMEN1THRBKMT2A | |
| SCHEMBL15510919 | 0.95 | EPHX1 (0.64) | EPHX1HTTMEN1THRBKMT2A | |
| SCHEMBL15511002 | 0.95 | EPHX1 (0.64) | EPHX1HTTMEN1THRBKMT2A | |
| SCHEMBL14051928 | 0.95 | EPHX1 (0.64) | EPHX1HTTMEN1THRBKMT2A | |
| SCHEMBL2599824 | 0.93 | EPHX1 (0.59) | EPHX1HTTMEN1THRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689868-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Arvinas Operations, Inc. (US) | 2020-08-05 | — | — | EP | disclosed |