Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 5/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2226816 | 0.86 | MC4R (0.68) | MC4RKCNH2L3MBTL1TSHRHSD17B10 | |
| SCHEMBL23951395 | 0.85 | MC4R (0.77) | MC4RKCNH2L3MBTL1TSHRHSD17B10 | |
| SCHEMBL13364991 | 0.85 | MC4R (0.77) | MC4RKCNH2L3MBTL1TSHRHSD17B10 | |
| SCHEMBL23951303 | 0.85 | MC4R (0.77) | MC4RKCNH2L3MBTL1TSHRHSD17B10 | |
| Hydrochloric Acid SCHEMBL23923790 | 0.83 | MC4R (0.75) | MC4RKCNH2L3MBTL1TSHRHSD17B10 | |
| SCHEMBL3346555 | 0.81 | MC4R (0.68) | MC4RKCNH2L3MBTL1TSHRHSD17B10 | |
| SCHEMBL13365063 | 0.81 | MC4R (0.68) | MC4RKCNH2TSHRHSD17B10ALDH1A1 | |
| SCHEMBL3353248 | 0.81 | MC4R (0.68) | MC4RKCNH2TSHRHSD17B10ALDH1A1 | |
| SCHEMBL3353044 | 0.79 | KCNH2 (0.46) | MC4RKCNH2TSHRSLC6A2ALDH1A1 | |
| SCHEMBL13364990 | 0.79 | KCNH2 (0.69) | MC4RKCNH2L3MBTL1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513052-A1 | PYRROLIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011085886-A1 | PYRROLIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |