Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | LATS1 | O95835 | 1/20 | 0.44 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | NFATC1 | O95644 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | CPT1A | P50416 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2229950 | 1.00 | HTT (0.50) | HTTPIM1LATS1HASPINRAB9A | |
| SCHEMBL2235 | 0.80 | NPC1 (0.62) | PIM1RAB9ANPC1TDP1RECQL | |
| SCHEMBL2236 | 0.80 | NPC1 (0.62) | PIM1RAB9ANPC1TDP1RECQL | |
| SCHEMBL16205468 | 0.76 | PIM1 (0.48) | HTTPIM1RAB9ANPC1TDP1 | |
| SCHEMBL3217902 | 0.76 | HASPIN (0.64) | HASPINCYP2C19CYP2D6CYP2C9DYRK1A | |
| SCHEMBL30924488 | 0.76 | HASPIN (0.64) | HASPINCYP2C19CYP2D6CYP2C9DYRK1A | |
| SCHEMBL30101234 | 0.76 | DYRK1A (0.51) | HASPINTDP1CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL2052704 | 0.76 | DYRK1A (0.51) | HASPINTDP1CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL13991177 | 0.76 | MAP2K1 (0.58) | HTTPIM1DYRK1ARECQLLMNA | |
| SCHEMBL13357712 | 0.76 | MAP2K1 (0.58) | HTTPIM1DYRK1ARECQLLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110183975-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | GOTO YASUHIRO | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183975-A1 | NOVEL 6-AZAINDOLE AMINOPYRIMIDINE DERIVATIVES HAVING NIK INHIBITORY ACTIVITY | BRIX1, REL, CNKSR1 | HTT 3956/4885PIM1 1529/4885LATS1 808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.