Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2229983 | 1.00 | MAPT (0.45) | MAPTGAAALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL21326162 | 0.81 | LMNA (0.46) | MAPTALDH1A1CYP1A2CYP2C19RAB9A | |
| SCHEMBL21326166 | 0.81 | LMNA (0.46) | MAPTALDH1A1CYP1A2CYP2C19RAB9A | |
| SCHEMBL6426292 | 0.75 | NAPRT (0.53) | MAPTGAAALDH1A1SMN1; SMN2NAPRT | |
| SCHEMBL11496108 | 0.75 | MAPT (0.51) | MAPTGAAALDH1A1SMN1; SMN2CYP2C19 | |
| SCHEMBL27935499 | 0.72 | NAPRT (0.50) | MAPTGAAALDH1A1SMN1; SMN2NAPRT | |
| SCHEMBL7549566 | 0.72 | CES2 (0.47) | MAPTGAAALDH1A1KMT2AHTT | |
| SCHEMBL16142592 | 0.71 | CYP1A2 (0.56) | MAPTGAAALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL21598047 | 0.70 | KMT2A (0.44) | MAPTGAAALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL27512055 | 0.70 | SMN1; SMN2 (0.54) | MAPTGAAALDH1A1SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011091410-A1 | TRPV4 ANTAGONISTS | GLAXOS SMITHKLINE LLC (US) | 2011-07-28 | — | — | WO | disclosed |