Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2767477 | 0.81 | KMT2A (0.35) | KMT2AMEN1HTTTDP1CYP2D6 | |
| SCHEMBL31248906 | 0.81 | KMT2A (0.35) | KMT2AMEN1HTTTDP1CYP2D6 | |
| SCHEMBL5067867 | 0.76 | KDM4E (0.36) | KMT2AHTTCYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL31426069 | 0.76 | KDM4E (0.36) | KMT2AHTTCYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL15817308 | 0.75 | S1PR2 (0.40) | KMT2AMEN1HTTTDP1CYP2D6 | |
| SCHEMBL9476338 | 0.74 | ALDH1A1 (0.46) | KMT2AMEN1HTTTDP1ALDH1A1 | |
| SCHEMBL29462391 | 0.72 | TDP1 (0.48) | KMT2AMEN1HTTTDP1CYP2D6 | |
| SCHEMBL259983 | 0.72 | TDP1 (0.48) | KMT2AMEN1HTTTDP1CYP2D6 | |
| Hydrochloric Acid SCHEMBL5778836 | 0.70 | TDP1 (0.46) | KMT2AMEN1HTTTDP1ALDH1A1 | |
| SCHEMBL23137233 | 0.70 | ALDH1A1 (0.33) | KMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020159905-A1 | PYRAZOLOPYRIDINES AND TRIAZOLOPYRIDINES AS A2A / A2B INHIBITORS | INCYTE CORPORATION (US) | 2020-08-06 | — | — | WO | disclosed |