Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | BRD9 | Q9H8M2 | 7/20 | 0.44 |
| ▸ | BRD4 | O60885 | 6/20 | 0.44 |
| ▸ | BRD7 | Q9NPI1 | 5/20 | 0.44 |
| ▸ | BRD2 | P25440 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TAF1 | P21675 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19869934 | 0.78 | BRD9 (0.45) | BRD9BRD4BRD7BRD2HTR7 | |
| SCHEMBL22302148 | 0.78 | BRD9 (0.45) | BRD9BRD4BRD7BRD2MAPT | |
| SCHEMBL29274530 | 0.77 | MAPT (0.51) | PTGS2MAPTLMNAMEN1ALDH1A1 | |
| SCHEMBL918847 | 0.75 | PTGS2 (0.59) | PTGS2ALDH1A1CYP3A4KDM4EHTR2A | |
| SCHEMBL12895704 | 0.75 | PTGS2 (0.59) | PTGS2MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL21227799 | 0.73 | PTGS2 (0.40) | PTGS2MAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL19869865 | 0.73 | BRD9 (0.42) | BRD9BRD4BRD7BRD2MAPT | |
| SCHEMBL3214081 | 0.72 | HSD17B10 (0.39) | PTGS2BRD9BRD4MAPTLMNA | |
| SCHEMBL30374 | 0.72 | PTGS2 (1.00) | PTGS2MAPTCYP3A4KDM4EHTR2A | |
| SCHEMBL13754262 | 0.72 | PTGS2 (0.67) | PTGS2MEN1ALDH1A1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020160193-A2 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |