Orotic Acid

Orotic Acid

SCHEMBL2230346

NC(=O)c1[nH]cnc1N.O=C(O)c1cc(=O)[nH]c(=O)[nH]1

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GDA Q9Y2T3 1/20 0.59
LMNA P02545 3/20 0.57
ALDH1A1 P00352 2/20 0.57
TSHR P16473 4/20 0.42
CYP2C19 P33261 1/20 0.40
CYP1A2 P05177 1/20 0.38
DAO P14920 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.34
ALOX15 P16050 1/20 0.34
NFKB1 P19838 1/20 0.34
BLM P54132 1/20 0.34
NGFR P08138 1/20 0.34
PAX8 Q06710 1/20 0.33
KDM4E B2RXH2 1/20 0.33
MMP9 P14780 1/20 0.33
PIM1 P11309 1/20 0.33
GPR84 Q9NQS5 4/20 0.32
PDPK1 O15530 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Orotic Acid SCHEMBL1650271 0.99 GDA (0.58) GDALMNAALDH1A1TSHRCYP2C19
Orotic Acid SCHEMBL2228874 0.81 ALDH1A1 (0.57) GDALMNAALDH1A1TSHRCYP2C19
Orotic Acid SCHEMBL867981 0.81 ALDH1A1 (0.57) GDALMNAALDH1A1TSHRCYP2C19
Orotic Acid SCHEMBL7929837 0.80 ALDH1A1 (0.55) GDALMNAALDH1A1TSHRCYP2C19
Orotic Acid SCHEMBL7926780 0.80 ALDH1A1 (0.55) GDALMNAALDH1A1TSHRCYP2C19
Orotic Acid SCHEMBL2269064 0.77 ALDH1A1 (0.88) LMNAALDH1A1TSHRCYP2C19CYP1A2
SCHEMBL94902 0.77
Orotic Acid SCHEMBL867980 0.76 ALDH1A1 (0.54) LMNAALDH1A1TSHRCYP2C19CYP1A2
Orotic Acid SCHEMBL2228871 0.76 ALDH1A1 (0.54) LMNAALDH1A1TSHRCYP2C19CYP1A2
Hydrochloric Acid SCHEMBL1776088 0.75 GDA (0.96) GDALMNAALDH1A1TSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120152742-A Polymer with dual therapeutic agents 索尼集团公司 2025-06-13 CN claimed
CN-119997980-A Polymers with steroids or vitamins 索尼集团公司 2025-05-13 CN claimed
CN-119874621-A Pharmaceutical composition containing pyrazole ether compound and application thereof 上海晓明检测技术服务有限公司 2025-04-25 CN claimed
CN-217549703-U Blending tank for preparing rice blast amide 江苏长青农化股份有限公司 2022-10-11 CN claimed
CN-114478314-A Synthesis method of fenoxanil 江苏长青农化股份有限公司 2022-05-13 CN claimed
CN-119874621-A Pharmaceutical composition containing pyrazole ether compound and application thereof 上海晓明检测技术服务有限公司 2025-04-25 CN disclosed
CN-118987015-A Application of antisense oligonucleotide in preparation of medicine for treating breast cancer 北京悦康科创医药科技股份有限公司 2024-11-22 CN disclosed
CN-117510485-A Isoxazoline compounds for controlling invertebrate pests FMC公司 2024-02-06 CN disclosed
CN-117510483-A Isoxazoline compounds for controlling invertebrate pests FMC公司 2024-02-06 CN disclosed
CN-111566108-B Heterocyclic compound and harmful arthropod control agent containing same 住友化学株式会社 2023-03-28 CN disclosed
CN-105254634-B 2, 3-dihydroimidazo [1,2-c ] quinazoline substituted derivatives useful in the treatment of hyperproliferative diseases and angiogenesis-related diseases 拜耳知识产权有限责任公司 2022-05-27 CN disclosed
CN-114340391-A Polymers for spray drift control of pesticide sprays 巴斯夫欧洲公司 2022-04-12 CN disclosed
US-6239137-B1 IN PRECANCEROUS AND CANCEROUS CELLS. SAVVIPHARM INC 2001-05-29 US disclosed
US-6184227-B1 ADMINISTERING A DETOXIFYING DOSAGE TO PATIENT TO PREVENT TISSUE DAMAGE BY ALCOHOLIC BEVERAGES, REACTIVE DRUG METABOLITES OR DIETARY TOXINS SAVVIPHARM INC. 2001-02-06 US disclosed
WO-2000078311-A1 SALTS OF AMINOIMIDAZOLE CARBOXAMIDE USEFUL IN THE PREVENTION AND TREATMENT OF LIVER DISEASES SAVVIPHARM INC. (US) 2000-12-28 WO disclosed
US-5912346-A Treatment and prevention of neoplasms with salts of aminoimidazole carboxamide and 5-amino or substituted amino 1,2,3-triazoles CONSTANTIA GRUPPE (AT) 1999-06-15 US disclosed
US-5861406-A ANTICARCINOGENIC AGENTS AND ANTITUMOR AGENTS CONSTANTIA GRUPPE (AT) 1999-01-19 US disclosed
EP-0840608-A1 TREATMENT AND PREVENTION OF NEOPLASMS WITH SALTS OF AMINOIMIDAZOLE CARBOXAMIDE AND 5-AMINO OR SUBSTITUTED AMINO 1,2,3-TRIAZOLES Constantia Gruppe (AT) 1998-05-13 EP disclosed
US-5728707-A Treatment and prevention of primary and metastatic neoplasms with salts of aminoimidazole carboxamide CONSTANTIA GRUPPE (AT) 1998-03-17 US disclosed
WO-1997003668-A1 TREATMENT AND PREVENTION OF NEOPLASMS WITH SALTS OF AMINOIMIDAZOLE CARBOXAMIDE AND 5-AMINO OR SUBSTITUTED AMINO 1,2,3-TRIAZOLES CONSTANTIA GRUPPE (AT) 1997-02-06 WO disclosed