Orotic Acid

Orotic Acid

SCHEMBL867981

NC(=O)c1nc[nH]c1N.O=C(O)c1cc(=O)[nH]c(=O)[nH]1

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.57
LMNA P02545 1/20 0.57
TSHR P16473 2/20 0.42
CYP1A2 P05177 2/20 0.41
CYP2C19 P33261 3/20 0.40
GPR84 Q9NQS5 4/20 0.35
GDA Q9Y2T3 2/20 0.34
ALOX15 P16050 1/20 0.34
NFKB1 P19838 1/20 0.34
BLM P54132 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
DAO P14920 2/20 0.34
NGFR P08138 1/20 0.34
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
HSD17B10 Q99714 2/20 0.32
ABL1 P00519 1/20 0.31
RIN1 Q13671 1/20 0.31
KDM4E B2RXH2 1/20 0.31
GRIN2D O15399 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Orotic Acid SCHEMBL2228874 1.00 ALDH1A1 (0.57) ALDH1A1LMNATSHRCYP1A2CYP2C19
Orotic Acid SCHEMBL7929837 0.99 ALDH1A1 (0.55) ALDH1A1LMNATSHRCYP1A2CYP2C19
Orotic Acid SCHEMBL7926780 0.99 ALDH1A1 (0.55) ALDH1A1LMNATSHRCYP1A2CYP2C19
Orotic Acid SCHEMBL867980 0.90 ALDH1A1 (0.54) ALDH1A1LMNATSHRCYP1A2CYP2C19
Orotic Acid SCHEMBL2228871 0.90 ALDH1A1 (0.54) ALDH1A1LMNATSHRCYP1A2CYP2C19
Orotic Acid SCHEMBL7926736 0.88 ALDH1A1 (0.53) ALDH1A1LMNATSHRCYP1A2CYP2C19
Orotic Acid SCHEMBL7926776 0.88 ALDH1A1 (0.53) ALDH1A1LMNATSHRCYP1A2CYP2C19
Orotic Acid SCHEMBL2230346 0.81 GDA (0.59) ALDH1A1LMNATSHRCYP1A2CYP2C19
Orotic Acid SCHEMBL1650271 0.80 GDA (0.58) ALDH1A1LMNATSHRCYP1A2CYP2C19
Orotic Acid SCHEMBL2269064 0.77 ALDH1A1 (0.88) ALDH1A1LMNATSHRCYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 478 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105348410-B One kind polysaccharide containing iodine and its synthetic method and application 中山大学 2019-02-26 CN claimed
CN-109096963-A A kind of adhesive for labels and preparation method thereof that suitable low temperature uses 定州秧浦新材科技开发有限公司 2018-12-28 CN claimed
CN-108822777-A The strong buildings waterproof adhesive and preparation method thereof of a kind of good weatherability, cohesive force 定州秧浦新材科技开发有限公司 2018-11-16 CN claimed
CN-108822776-A A kind of environment-friendly type high performance buildings waterproof adhesive and preparation method thereof 蔡文剑 2018-11-16 CN claimed
CN-108795350-A A kind of environment-friendly type adhesive for labels and preparation method thereof 蔡文剑 2018-11-13 CN claimed
CN-108752912-A A kind of macromolecule resin based composites 重庆新康意安得达尔新材料有限公司 2018-11-06 CN claimed
CN-106236726-B Orazamide coated slow release piece and preparation method thereof 湖南中南制药有限责任公司 2018-03-20 CN claimed
CN-107325053-A A kind of refined and discoloration method of Orazamide 广东华南药业集团有限公司 2017-11-07 CN claimed
CN-102952375-B A kind of special screw spike of thermoset ultrahigh-molecular epoxy resin railway 杭州大固新材料有限公司 2017-09-26 CN claimed
CN-102952371-B Modified thermosetting ultrahigh-molecular epoxy resin marine board 杭州大固新材料有限公司 2017-05-10 CN claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
US-5861406-A ANTICARCINOGENIC AGENTS AND ANTITUMOR AGENTS CONSTANTIA GRUPPE (AT) 1999-01-19 US claimed
CN-1040980-C Second messenger cell signaling inhibitors CELL THERAPEUTICS INC (US) 1998-12-02 CN claimed
EP-0840608-A1 TREATMENT AND PREVENTION OF NEOPLASMS WITH SALTS OF AMINOIMIDAZOLE CARBOXAMIDE AND 5-AMINO OR SUBSTITUTED AMINO 1,2,3-TRIAZOLES Constantia Gruppe (AT) 1998-05-13 EP claimed
US-5728707-A Treatment and prevention of primary and metastatic neoplasms with salts of aminoimidazole carboxamide CONSTANTIA GRUPPE (AT) 1998-03-17 US claimed
WO-1997003668-A1 TREATMENT AND PREVENTION OF NEOPLASMS WITH SALTS OF AMINOIMIDAZOLE CARBOXAMIDE AND 5-AMINO OR SUBSTITUTED AMINO 1,2,3-TRIAZOLES CONSTANTIA GRUPPE (AT) 1997-02-06 WO claimed
CN-1122600-A Inhibitors of second messenger cell signaling CELL THERAPEUTICS INC (US) 1996-05-15 CN claimed
CN-1022914-C Process for preparation of 1, 3-disubstituted piperidine derivatives PFIZER (US) 1993-12-01 CN claimed
CN-1070647-A Preparation has the method for optically active false bufotoxin amidoalcohol WEIYAN SUN (CN) 1993-04-07 CN claimed
CN-1039415-A New 1, the preparation method of 3-3-disubstituted piperidine derivatives PFIZER (GB) 1990-02-07 CN claimed