Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PRKX | P51817 | 1/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22290407 | 0.91 | SMARCA2 (0.44) | SMARCA2SMARCA4AURKAKLKB1CYP3A4 | |
| SCHEMBL22290930 | 0.80 | SMARCA2 (0.58) | SMARCA2SMARCA4CYP3A4CYP2C9ROCK2 | |
| SCHEMBL22306187 | 0.79 | AURKA (0.41) | AURKACYP3A4CYP2C9BLMROCK2 | |
| SCHEMBL31368278 | 0.76 | SMARCA2 (0.42) | SMARCA2SMARCA4AURKAKLKB1CYP3A4 | |
| SCHEMBL22290613 | 0.73 | SMARCA2 (0.48) | SMARCA2SMARCA4KLKB1CYP3A4CYP2C9 | |
| SCHEMBL22290676 | 0.72 | SMARCA2 (0.53) | SMARCA2SMARCA4CYP3A4CYP2C9ROCK2 | |
| SCHEMBL22290758 | 0.72 | SMARCA2 (0.69) | SMARCA2SMARCA4CYP3A4CYP2C9ROCK2 | |
| SCHEMBL22290720 | 0.71 | SMARCA2 (0.64) | SMARCA2SMARCA4CYP3A4CYP2C9ROCK2 | |
| SCHEMBL22290717 | 0.71 | SMARCA2 (0.64) | SMARCA2SMARCA4CYP3A4CYP2C9ROCK2 | |
| SCHEMBL25498927 | 0.71 | AURKA (0.41) | AURKAROCK2GRM5ROCK1MAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020160180-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |