Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CD4 | P01730 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269988 | 0.80 | KMT2A (0.47) | PKMALDH1A1HTTUSP2ALOX15 | |
| SCHEMBL21724349 | 0.74 | ALDH1A1 (0.50) | PKMALDH1A1HTTUSP2ALOX15 | |
| SCHEMBL28226553 | 0.74 | ALDH1A1 (0.50) | PKMALDH1A1HTTUSP2ALOX15 | |
| SCHEMBL568507 | 0.74 | KMT2A (0.49) | PKMALDH1A1HTTUSP2ALOX15 | |
| SCHEMBL568960 | 0.72 | PKM (0.46) | PKMALDH1A1HTTUSP2ALOX15 | |
| SCHEMBL568616 | 0.72 | PKM (0.46) | PKMALDH1A1HTTUSP2ALOX15 | |
| SCHEMBL3258659 | 0.72 | PKM (0.46) | PKMALDH1A1HTTUSP2ALOX15 | |
| SCHEMBL568658 | 0.72 | ALDH1A1 (0.51) | PKMALDH1A1HTTUSP2ALOX15 | |
| SCHEMBL20945468 | 0.71 | F2 (0.51) | PKMALDH1A1HTTUSP2ALOX15 | |
| SCHEMBL5271607 | 0.71 | KMT2A (0.49) | PKMALDH1A1HTTUSP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346868-A1 | AZAINDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010036632-A1 | AZAINDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-01 | — | — | WO | disclosed |