SCHEMBL22307385

SCHEMBL22307385

N#CC(C#N)=CNCc1ccc(F)cc1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PLA2G1B P04054 2/20 0.43
ATG4B Q9Y4P1 2/20 0.43
ALDH1A1 P00352 3/20 0.41
RAB9A P51151 2/20 0.40
MAPT P10636 1/20 0.40
GLA P06280 1/20 0.40
LMNA P02545 2/20 0.39
APP P05067 1/20 0.39
SNCA P37840 1/20 0.39
CHRM2 P08172 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
HTT P42858 1/20 0.37
DPP7 Q9UHL4 3/20 0.36
VNN1 O95497 1/20 0.36
DPP4 P27487 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22307309 0.91 KMT2A (0.38) ALDH1A1MAPTLMNACYP2C19
SCHEMBL3937741 0.81 ADH1B (0.48) ALDH1A1MAPTLMNAAPPSNCA
SCHEMBL22307312 0.78 EPHX2 (0.47) ALDH1A1RAB9AMAPTLMNACYP2C19
SCHEMBL17261148 0.76 PLA2G1B (0.47) PLA2G1BATG4BALDH1A1RAB9AMAPT
SCHEMBL22307305 0.75 MAPT (0.39) ALDH1A1RAB9AMAPTLMNACYP3A4
SCHEMBL22307234 0.75 TSHR (0.44) PLA2G1BATG4BALDH1A1CYP2D6CYP2C9
SCHEMBL22307316 0.73 KMT2A (0.58) ALDH1A1RAB9AMAPTLMNAHTT
SCHEMBL22306357 0.72 GAA (0.41) ALDH1A1MAPTLMNAHTT
SCHEMBL5641254 0.71 ALDH1A1 (0.41) PLA2G1BATG4BALDH1A1RAB9AMAPT
SCHEMBL3943662 0.70 NPC1 (0.51) ALDH1A1RAB9ACYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020156298-A1 APPLICATION OF MALONONITRILE COMPOUND AS BACTERICIDE 沈阳化工大学 2020-08-06 WO disclosed