SCHEMBL22307393

SCHEMBL22307393

N#CC(C#N)=CNc1ccc(Cl)c(Cl)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.49
GAA P10253 3/20 0.45
EPHX1 P07099 2/20 0.44
EPHX2 P34913 2/20 0.44
KDM4E B2RXH2 2/20 0.44
NPC1 O15118 3/20 0.41
MAPT P10636 3/20 0.41
HTT P42858 2/20 0.41
RAB9A P51151 2/20 0.41
CA2 P00918 1/20 0.41
CA4 P22748 1/20 0.41
CA5A P35218 1/20 0.41
CA9 Q16790 1/20 0.41
MEN1 O00255 3/20 0.40
ALDH1A1 P00352 1/20 0.40
POLB P06746 1/20 0.40
IDO1 P14902 1/20 0.40
PKM P14618 1/20 0.40
GLA P06280 1/20 0.40
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3934982 0.79 KMT2A (0.58) KMT2AGAAKDM4EMAPTHTT
SCHEMBL11299688 0.75 GAA (0.49) KMT2AGAAKDM4EMAPTMEN1
SCHEMBL11547314 0.73 ALDH1A1 (0.37) KMT2AGAAKDM4EMAPTHTT
SCHEMBL22307234 0.73 TSHR (0.44) KMT2AMEN1ALDH1A1POLBIDO1
SCHEMBL10619027 0.71 TRPA1 (0.33) KMT2AGAAKDM4EMAPTHTT
SCHEMBL10992979 0.71 TRPA1 (0.33) KMT2AGAAKDM4EMAPTHTT
SCHEMBL22307316 0.71 KMT2A (0.58) KMT2AGAAKDM4ENPC1MAPT
SCHEMBL22307389 0.71 KMT2A (0.58) KMT2AGAAKDM4EMAPTHTT
SCHEMBL12484685 0.71 KMT2A (0.58) KMT2AGAAKDM4ENPC1MAPT
SCHEMBL11611806 0.70 IDO1 (0.56) KMT2AGAAEPHX1EPHX2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020156298-A1 APPLICATION OF MALONONITRILE COMPOUND AS BACTERICIDE 沈阳化工大学 2020-08-06 WO disclosed