Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4215079 | 0.84 | MAOB (0.43) | MAPTPOLBGAALMNAKCNH2 | |
| SCHEMBL7355155 | 0.83 | KCNH2 (0.44) | MAPTPOLBGAALMNAPDE3B | |
| SCHEMBL4361638 | 0.83 | AXL (0.52) | MAPTGAAPDE3BPDE3AKCNH2 | |
| SCHEMBL22309145 | 0.80 | PDE3B (0.42) | PDE3BPDE3A | |
| SCHEMBL10803822 | 0.80 | KDM4E (0.41) | TDP2IGF1RKDM4ENPC1RAB9A | |
| SCHEMBL10799782 | 0.80 | NOTUM (0.40) | PDE3BPDE3AKMT2AMEN1CCNB2 | |
| SCHEMBL10802190 | 0.78 | MAPT (0.42) | MAPTGAALMNASMN1; SMN2KMT2A | |
| SCHEMBL4211464 | 0.76 | PDE3B (0.51) | MAPTPOLBGAAPDE3BPDE3A | |
| SCHEMBL10803746 | 0.76 | NISCH (0.58) | MAPTPOLBGAAPDE3BPDE3A | |
| SCHEMBL22308851 | 0.74 | PDE3B (0.54) | MAPTLMNAPDE3BPDE3AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020157189-A1 | 1,2,4-TRIAZIN-6(1H)-ONE COMPOUNDS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | WO | disclosed |