Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4361638 | 0.85 | AXL (0.52) | KCNH2NISCHPDE3BPDE3AMAPT | |
| SCHEMBL22308341 | 0.83 | MAPT (0.39) | KCNH2PDE3BPDE3AMAPTLMNA | |
| SCHEMBL7284129 | 0.81 | CYP3A4 (0.39) | KCNH2PDE3BPDE3ALMNAAXL | |
| SCHEMBL4215079 | 0.81 | MAOB (0.43) | KCNH2MAPTLMNAPOLBGAA | |
| SCHEMBL10781878 | 0.81 | NISCH (0.49) | KCNH2NISCH | |
| SCHEMBL9669186 | 0.78 | CDC7 (0.40) | KCNH2PDE3BPDE3ACDC7 | |
| SCHEMBL22309168 | 0.78 | PDE3B (0.53) | PDE3BPDE3A | |
| SCHEMBL10799782 | 0.78 | NOTUM (0.40) | PDE3BPDE3ADDB1CRBN | |
| SCHEMBL10803822 | 0.78 | KDM4E (0.41) | CRBNNPC1RAB9A | |
| SCHEMBL10806102 | 0.76 | MKNK2 (0.41) | CDC7AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4788194-A | CARDIOTONIC AGENTS, HYPOTENSIVE AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-11-29 | — | — | US | claimed |
| EP-0618204-B1 | HETEROCYCLIC COMPOUND AND CARDIOTONIC CONTAINING THE SAME AS ACTIVE INGREDIENT | ZENYAKU KOGYO KK (JP) | 1998-06-10 | — | — | EP | disclosed |
| US-5574033-A | Heterocyclic compound and cardiotonic agent containing the same as effective component | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1996-11-12 | — | — | US | disclosed |
| US-5446042-A | Heterocyclic compound and cardiotonic agent containing the same as effective component | ZENYAKU KOGYO KABUSHIKI KAISHA (JP) | 1995-08-29 | — | — | US | disclosed |
| EP-0618204-A1 | HETEROCYCLIC COMPOUND AND CARDIOTONIC CONTAINING THE SAME AS ACTIVE INGREDIENT | ZENYAKU KOGYO KABUSHIKIKAISHA (JP) | 1994-10-05 | — | — | EP | disclosed |
| US-4788194-A | CARDIOTONIC AGENTS, HYPOTENSIVE AGENTS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-11-29 | — | — | US | disclosed |
| US-4716164-A | CARDIOTONIC, HYPOTENSIVE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-12-29 | — | — | US | disclosed |
| US-4558045-A | CARDIOTONIC AND HYPOTENSIVE ACTIVITY | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1985-12-10 | — | — | US | disclosed |
| US-4489073-A | HYPOTENSIVE AND CARDIOTONIC AGENTS | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1984-12-18 | — | — | US | disclosed |
| EP-0085227-A1 | Thiadiazine derivatives, and pharmaceutical compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-08-10 | — | — | EP | disclosed |