Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4196668 | 0.88 | PARP1 (0.43) | PDE3BPDE3ANISCH | |
| SCHEMBL22309155 | 0.84 | PDE3B (0.47) | PDE3BPDE3AKMO | |
| SCHEMBL22308341 | 0.80 | MAPT (0.39) | PDE3BPDE3A | |
| SCHEMBL4215079 | 0.78 | MAOB (0.43) | NOTUM | |
| SCHEMBL22308892 | 0.78 | PDE3B (0.62) | PDE3BPDE3A | |
| SCHEMBL22309151 | 0.78 | PDE3B (0.48) | PDE3BPDE3A | |
| SCHEMBL4211464 | 0.77 | PDE3B (0.51) | PDE3BPDE3ANOTUMNISCHKMO | |
| SCHEMBL10899939 | 0.76 | PGR (0.42) | NOTUMPGR | |
| SCHEMBL22308851 | 0.75 | PDE3B (0.54) | PDE3BPDE3ANOTUM | |
| SCHEMBL4215979 | 0.75 | PDE3B (0.32) | PDE3BPDE3APGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020157189-A1 | 1,2,4-TRIAZIN-6(1H)-ONE COMPOUNDS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | WO | disclosed |