Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.58 |
| ▸ | PDE4A | P27815 | 4/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | PDE1A | P54750 | 1/20 | 0.58 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.58 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.58 |
| ▸ | KLK1 | P06870 | 1/20 | 0.47 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2528772 | 0.91 | PDE4B (0.72) | ROCK2ROCK1PDE4BPDE4APDE4C | |
| SCHEMBL2229887 | 0.86 | ROCK2 (0.65) | ROCK2ROCK1PDE4BPDE4APDE4C | |
| SCHEMBL5583333 | 0.84 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL595831 | 0.84 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL13460360 | 0.84 | PDE4B (0.58) | ROCK2ROCK1PDE4BPDE4APDE4C | |
| SCHEMBL594783 | 0.81 | PDE4B (0.81) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL5134350 | 0.81 | PDE4B (0.81) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL16416682 | 0.80 | RPS6KA1 (0.48) | ROCK2ROCK1PDE4BPDE4APDE4C | |
| SCHEMBL1232022 | 0.79 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DCHRM1 | |
| SCHEMBL12446578 | 0.79 | ROCK2 (0.65) | ROCK2ROCK1PDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461336-B2 | Boron-containing small molecules | ANACOR PHARMACEUTICALS, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-8461336-B2 | Boron-containing small molecules | ANACOR PHARMACEUTICALS, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20110166104-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2011-07-07 | — | — | US | disclosed |
| US-20110166104-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2011-07-07 | — | — | US | disclosed |
| WO-2010028005-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010028005-A1 | BORON-CONTAINING SMALL MOLECULES | ANACOR PHARMACEUTICALS, INC. (US) | 2010-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166104-A1 | BORON-CONTAINING SMALL MOLECULES | NFKBIA, BCL6B, TNF | ROCK2 602/4885ROCK1 795/4885PDE4B 543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.