SCHEMBL2230911

SCHEMBL2230911

CNC(C(=O)O)C(O)C(C)C

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.41
SLC7A5 Q01650 1/20 0.35
ALDH1A1 P00352 4/20 0.34
SMN1; SMN2 Q16637 3/20 0.33
LMNA P02545 1/20 0.32
GAA P10253 1/20 0.32
HPGD P15428 1/20 0.32
PLA2G2A P14555 1/20 0.32
PLA2G5 P39877 1/20 0.32
KDM4E B2RXH2 1/20 0.31
FPR2 P25090 1/20 0.31
TSHR P16473 1/20 0.30
ADAMTS4 O75173 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2230916 1.00 TP53 (0.41) TP53SLC7A5ALDH1A1SMN1; SMN2LMNA
SCHEMBL8351936 1.00 TP53 (0.41) TP53SLC7A5ALDH1A1SMN1; SMN2LMNA
SCHEMBL43661 0.81
SCHEMBL43660 0.81
SCHEMBL716843 0.81 SMN1; SMN2 (0.41) TP53SLC7A5ALDH1A1SMN1; SMN2LMNA
SCHEMBL161931 0.81
SCHEMBL19080635 0.79
SCHEMBL21621510 0.79
SCHEMBL312336 0.79
SCHEMBL21673293 0.79

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6270957-B1 USEFUL IN THE TREATMENT AND PREVENTION OF HIV (HUMAN IMMUNODEFICIENCY VIRUS)-MEDIATED DISORDERS, INCLUDING AIDS (ACQUIRE IMMUNODEFICIENCY SYNDROME) WISCONSIN ALUMNI RESEARCH FOUNDATION 2001-08-07 US claimed
WO-1999010373-B1 NON-IMMUNOSUPPRESSIVE CYCLOSPORINS AND THEIR USE IN THE PREVENTION AND TREATMENT OF HIV INFECTION WISCONSIN ALUMNI RES FOUND (US) 1999-04-01 WO claimed
WO-1999010373-A1 NON-IMMUNOSUPPRESSIVE CYCLOSPORINS AND THEIR USE IN THE PREVENTION AND TREATMENT OF HIV INFECTION WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1999-03-04 WO claimed
EP-4100007-A1 ELONGATION FACTOR 1-ALPHA INHIBITORS AND USES THEREOF The Regents of the University of California (US) 2022-12-14 EP disclosed
WO-2021158899-A1 ELONGATION FACTOR 1-ALPHA INHIBITORS AND USES THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-08-12 WO disclosed
US-20110201642-A1 Bioactive Compounds BLUNT JOHN 2011-08-18 US disclosed
EP-2352746-A1 BIOACTIVE COMPOUNDS Universiti Teknologi Mara (MY) 2011-08-10 EP disclosed
WO-2010062159-A1 BIOACTIVE COMPOUNDS UNIVERSITI TEKNOLOGI MARA (MY) 2010-06-03 WO disclosed
US-6316405-B1 CYCLOSPORIN A, POLYPEPTIDES, COMPONENT OF AMYLOID PLAQUES FOUND IN NEUROLOGICAL DISORDERS SUCH AS ALZHEIMER'S DISEASE, MULTIPLE SCLEROSIS, AND AMYOTROPHIC LATERAL SCLEROSIS. THE CONJUGATES ARE USEFUL IN THE TREATMENT OF NEUROLOGICAL WISCONSIN ALUMNI RESEARCH FOUNDATION 2001-11-13 US disclosed
US-6270957-B1 USEFUL IN THE TREATMENT AND PREVENTION OF HIV (HUMAN IMMUNODEFICIENCY VIRUS)-MEDIATED DISORDERS, INCLUDING AIDS (ACQUIRE IMMUNODEFICIENCY SYNDROME) WISCONSIN ALUMNI RESEARCH FOUNDATION 2001-08-07 US disclosed
US-5948693-A COVALENTLY BONDING SIDE CHAIN OF SELECTED AMINO ACID TO SOLID SUPPORT VIA ACID-LABILE OR PHOTO-LABILE LINKER, PROTECTING C-TERMINUS, SYNTHESIZING POLYPEPTIDE ON N-TERMINUS, DEPROTECTING C-TERMINUS AND CYCLIZING POLYPEPTIDE WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1999-09-07 US disclosed
WO-1999010374-A1 CYCLOSPORIN A CONJUGATES AND USES THEREFOR WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1999-03-04 WO disclosed
WO-1999010373-A1 NON-IMMUNOSUPPRESSIVE CYCLOSPORINS AND THEIR USE IN THE PREVENTION AND TREATMENT OF HIV INFECTION WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1999-03-04 WO disclosed
WO-1998046247-A1 SOLID PHASE SYNTHESIS OF IMMUNOSUPPRESSIVE AGENTS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1998-10-22 WO disclosed
EP-0778847-A4 IMMUNOSTIMULATORY AGENTS WISCONSIN ALUMNI RES FOUND (US) 1998-01-07 EP disclosed
EP-0778847-A1 IMMUNOSTIMULATORY AGENTS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1997-06-18 EP disclosed
US-5639852-A ANALOGS OF CYCLOSPORIN A WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1997-06-17 US disclosed
WO-1996006857-A1 IMMUNOSTIMULATORY AGENTS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1996-03-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110201642-A1 Bioactive Compounds TPI1, XPO1, GDI1 TP53 291/4885SLC7A5 3811/4885ALDH1A1 1421/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.