Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 11/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCND3 | P30281 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22308892 | 0.86 | PDE3B (0.62) | PDE3BPDE3ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22309157 | 0.85 | PDE3B (0.59) | PDE3BPDE3ACDK4CCND3 | |
| SCHEMBL22309145 | 0.78 | PDE3B (0.42) | PDE3BPDE3A | |
| SCHEMBL22309166 | 0.73 | PDE3B (0.54) | PDE3BPDE3A | |
| SCHEMBL22308358 | 0.73 | PDE3B (0.44) | PDE3BPDE3ANPC1RAB9A | |
| SCHEMBL4196668 | 0.72 | PARP1 (0.43) | PDE3BPDE3A | |
| SCHEMBL22307790 | 0.71 | PDE3B (0.61) | PDE3BPDE3A | |
| SCHEMBL22307819 | 0.70 | PDE3B (0.60) | PDE3BPDE3A | |
| SCHEMBL22309150 | 0.70 | PDE3B (0.45) | PDE3BPDE3ASMN1; SMN2 | |
| SCHEMBL22309155 | 0.69 | PDE3B (0.47) | PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020157189-A1 | 1,2,4-TRIAZIN-6(1H)-ONE COMPOUNDS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 2020-08-06 | — | — | WO | disclosed |