Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28470470 | 0.81 | ESR1 (0.68) | ESR1ESR2EPHX1CES1CHRM1 | |
| SCHEMBL24086636 | 0.81 | RIPK1 (0.49) | RIPK1CYP2C19EPHX1CHRM2CHRM5 | |
| SCHEMBL5272417 | 0.80 | CYP2C19 (0.46) | ESR1ESR2RIPK1CYP2C19EPHX1 | |
| SCHEMBL4198436 | 0.77 | CYP2C19 (0.59) | CYP2C19EPHX1CHRM2CHRM5CHRM1 | |
| SCHEMBL27770637 | 0.77 | CYP2C19 (0.48) | RIPK1CYP2C19EPHX1CHRM2CHRM5 | |
| SCHEMBL468727 | 0.77 | CYP2C19 (0.59) | CYP2C19EPHX1CHRM2CHRM5CHRM1 | |
| SCHEMBL3689059 | 0.77 | CYP2C19 (0.59) | CYP2C19EPHX1CHRM2CHRM5CHRM1 | |
| SCHEMBL28229620 | 0.77 | CHRM2 (0.46) | CYP2C19CHRM2CHRM5CHRM1CHRM3 | |
| SCHEMBL2981738 | 0.77 | RIPK1 (0.65) | RIPK1MEN1KMT2A | |
| SCHEMBL2981739 | 0.77 | RIPK1 (0.65) | RIPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11117869-B2 | Compounds, compositions and methods for treatment of myopia | AERIE PHARMACEUTICALS, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200247760-A1 | Compounds, Compositions and Methods for Treatment of Myopia | ALCON INC. (CH) | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11117869-B2 | Compounds, compositions and methods for treatment of myopia | MYOC, HDAC8, PDE6C | ESR1 4459/4885ESR2 3278/4885RIPK1 2766/4885 |
| US-20200247760-A1 | Compounds, Compositions and Methods for Treatment of Myopia | MYOC, HDAC8, PDE6C | ESR1 4459/4885ESR2 3278/4885RIPK1 2766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.