Sugi Predict

Sugi Predict / Targets / MYOC

MYOC

Myocilin · Q99972 · MYOC on Sugi Atlas →

3,786 patent compounds predicted against MYOC, 3,204 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL4112043 SCHEMBL4112043 0.73 2/20
SCHEMBL4112213 SCHEMBL4112213 0.70 2/20
SCHEMBL4115432 SCHEMBL4115432 0.68 2/20
Nicarbazin Nicarbazin (SCHEMBL578675) 0.56 2/20
Urea Urea (SCHEMBL2156950) 0.55 2/20
SCHEMBL3884016 SCHEMBL3884016 0.54 2/20
SCHEMBL987822 SCHEMBL987822 0.52 2/20
SCHEMBL4329007 SCHEMBL4329007 0.52 2/20
SCHEMBL3461321 SCHEMBL3461321 0.52 2/20
SCHEMBL4233910 SCHEMBL4233910 0.52 2/20
SCHEMBL4236591 SCHEMBL4236591 0.52 2/20
SCHEMBL4236718 SCHEMBL4236718 0.51 2/20
Nicarbazin Nicarbazin (SCHEMBL578676) 0.50 2/20
SCHEMBL693083 SCHEMBL693083 0.49 2/20
Gw305074X Gw305074X (SCHEMBL149921) 1.00 1/20
Gw305074X Gw305074X (SCHEMBL149922) 1.00 1/20
SCHEMBL1177730 SCHEMBL1177730 0.79 1/20
SCHEMBL4690573 SCHEMBL4690573 0.79 1/20
SCHEMBL1394784 SCHEMBL1394784 0.79 1/20
SCHEMBL4726411 SCHEMBL4726411 0.79 1/20

Clinical trials — most relevant to MYOC by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effect of Myocilin Genetic Variants on Intraocular Pressure and Pressure Variation in Sitting and Supine Positions PHASE4COMPLETED
Effect of Beta Blockade on Left Ventricular Remodeling and Function in Moderate to Severe Asymptomatic Aortic Regurgitation PHASE4COMPLETED
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy PHASE2RECRUITING
Autologous Cultured Myoblasts (BioWhittaker) Transplanted Via Myocardial Injection PHASE1UNKNOWN
Genetic Testing in Primary Congenital Glaucoma Patients nanUNKNOWN
Natural History of Photoreceptor Degeneration in USH1B: Clinical Parameters and Validation of Functional Vision Tests in MYO7A nanRECRUITING
Transcutaneous Functional Magnetic Muscle Stimulation in Critically Ill nanUNKNOWN
CRISPR/Cas9 Instantaneous Gene Editing Therapy to Intraocular Hypertensive POAG With MYOC Mutation nanRECRUITING
Characteristics of Nondystrophic Myotonias nanCOMPLETED
Changes of microRNA Expression in Obstructive and Neurogenic Bladder Dysfunction nanCOMPLETED
Genetic Analysis of African-Americans With High Blood Pressure nanCOMPLETED
Exome Analysis in Hearing Impaired Patients nanUNKNOWN
Screening and Identification of Biomarkers for High Myopia by a Rapid Method nanUNKNOWN
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan nanENROLLING_BY_INVITATION
Genetic Analysis of Hereditary Disorders of Hearing and Balance nanCOMPLETED
Genetic and Biohumoral Factors Involved in Menière's Disease and Their Correlation With Phenotypes nanRECRUITING
The Role of microRNAs in Organ Remodeling in Lower Urinary Tract Dysfunction nanCOMPLETED
Study of Usher Syndromes, Type 1 and Type 2 nanCOMPLETED
Clinical and Genetic Studies in Families With Myopia and Related Diseases nanCOMPLETED
Otoferlin Patient Registry and Natural History Study nanRECRUITING
MRI-phenotyping of Patients With Pathogenic Anoctamin 5 Variants nanRECRUITING
Study on Moebius Syndrome and Congenital Facial Weakness Disorders nanCOMPLETED
Pediatric Cardiomyopathy Mutation Analysis nanRECRUITING
Multispectral Optoacoustic Tomography for Advanced Imaging of Centronuclear Myopathy nanRECRUITING
Study of Low Level Laser Therapy and Word Recognition in Hearing Impaired Individuals nanCOMPLETED
Classification, Functional Stratification and Biomarkers in Ciliopathy (CILLICORIRCM) nanCOMPLETED
Chronic Muscle Disuse in the Elderly nanCOMPLETED
Risk of Posterior Staphyloma in Highly Myopic Europeans : From Epidemiology to Anatomy. nanRECRUITING
CCM Italian Registry nanUNKNOWN
Mapping Novel Disease Genes for Dilated Cardiomyopathy nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a MYOC binder may also engage these)

ProteinNameSimilarity
Q863A3 — 1.000 Q863A3 →
Q866N2 — 1.000 Q866N2 →
Q9R1J4 — 1.000 Q9R1J4 →
Q594P2 — 1.000 Q594P2 →
Q2PT31 — 1.000 Q2PT31 →
O70624 — 1.000 O70624 →
Q9XTA3 — 1.000 Q9XTA3 →
Q3UZZ4 — 0.995 Q3UZZ4 →
Q0P3W2 — 0.995 Q0P3W2 →
Q8BHP7 — 0.994 Q8BHP7 →
Q29RB4 — 0.994 Q29RB4 →
O95897 — 0.992 O95897 →
Q8BM13 — 0.992 Q8BM13 →
Q6UWY5 — 0.991 Q6UWY5 →
Q80WL1 — 0.990 Q80WL1 →
P63056 — 0.989 P63056 →
P63057 — 0.989 P63057 →
Q66H86 — 0.988 Q66H86 →
Q6ZMI3 — 0.987 Q6ZMI3 →
A2BD09 — 0.987 A2BD09 →
Q96PB7 — 0.987 Q96PB7 →
Q62609 — 0.987 Q62609 →
Q68BL7 — 0.987 Q68BL7 →
Q96PQ0 — 0.986 Q96PQ0 →
Q8BMF8 — 0.986 Q8BMF8 →
Q62443 — 0.986 Q62443 →
Q6UX06 — 0.986 Q6UX06 →
Q14112 — 0.986 Q14112 →
Q9QZC2 — 0.985 Q9QZC2 →
Q9JLC4 — 0.985 Q9JLC4 →