SCHEMBL223145

SCHEMBL223145

O=Cc1cccc(Br)c1F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 3/20 0.47
LMNA P02545 2/20 0.46
MEN1 O00255 1/20 0.46
THRB P10828 1/20 0.46
BLM P54132 1/20 0.46
KMT2A Q03164 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
CYP2A6 P11509 2/20 0.44
TRIM24 O15164 2/20 0.42
TRIM33 Q9UPN9 2/20 0.42
ALDH1A1 P00352 3/20 0.38
TSHR P16473 1/20 0.38
PIM1 P11309 2/20 0.38
PIM3 Q86V86 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
GAA P10253 1/20 0.38
MAPT P10636 1/20 0.38
HSD11B1 P28845 1/20 0.36
PIM2 Q9P1W9 1/20 0.35
HPGD P15428 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29525702 1.00 ERN1 (0.47) ERN1LMNAMEN1THRBBLM
SCHEMBL30037631 1.00 ERN1 (0.47) ERN1LMNAMEN1THRBBLM
SCHEMBL6853865 0.83 KMT2A (0.58) ERN1LMNAMEN1THRBBLM
SCHEMBL29390677 0.79 TDP1 (0.36) ERN1LMNAMEN1THRBBLM
SCHEMBL898807 0.79 TDP1 (0.36) ERN1LMNAMEN1THRBBLM
SCHEMBL22675468 0.78 KCNJ1 (0.37) ERN1LMNAMEN1THRBBLM
SCHEMBL22675473 0.78 ALDH1A1 (0.37) ERN1LMNAMEN1THRBBLM
SCHEMBL16954945 0.77 MAPT (0.41) ERN1LMNAMEN1KMT2AALDH1A1
SCHEMBL6873694 0.77 LMNA (0.38) LMNASMN1; SMN2GAAMAPTHSD11B1
SCHEMBL2945596 0.77 ALDH1A1 (0.38) LMNAALDH1A1SMN1; SMN2GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 687 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113264819-B Method for rapidly synthesizing 3-bromo-2-fluorobenzaldehyde based on continuous flow reaction technology 都创(上海)医药开发有限公司 2024-11-05 CN claimed
CN-118546092-A Synthesis method of 7-bromo-1H-indazole-3-methyl formate 南通大学 2024-08-27 CN claimed
CN-113264819-A Method for rapidly synthesizing 3-bromo-2-fluorobenzaldehyde based on continuous flow reaction technology 都创(上海)医药开发有限公司 2021-08-17 CN claimed
CN-109651375-A A kind of tetrahydro quinazoline derivative and its synthetic method and application 上海应用技术大学 2019-04-19 CN claimed
CN-109312618-A For hydraulic fracturing and for the method and composition of tracer water flooding 光谱追踪服务有限责任公司 2019-02-05 CN claimed
US-10017684-B2 Method and compositions for hydraulic fracturing and for tracing formation water SPECTRUM TRACER SERVICES, LLC (US) 2018-07-10 US claimed
CN-108057417-A For the modified zeolite adsorbent of benzene in Adsorption wastewater from chemical industry 北京益清源环保科技有限公司 2018-05-22 CN claimed
US-20170306217-A1 METHOD AND COMPOSITIONS FOR HYDRAULIC FRACTURING AND FOR TRACING FORMATION WATER NCS Multistage, LLC 2017-10-26 US claimed
EP-4698520-A1 RAF-MEK PROTEIN COMPLEX MODULATORS AND METHODS OF USE THEREOF Gandeeva Therapeutics, Inc. (US) 2026-02-25 EP disclosed
EP-3891149-B1 RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF SUNSHINE LAKE PHARMA CO LTD (CN) 2026-01-28 EP disclosed
EP-4673139-A1 NBD1 MODULATORS AND METHODS OF USING THE SAME Sionna Therapeutics Inc. (US) 2026-01-07 EP disclosed
EP-4667458-A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CANCER, COMPRISING SOS1 INHIBITOR AND ANTICANCER DRUG Kanaph Therapeutics Inc. (KR) 2025-12-24 EP disclosed
EP-4667464-A1 AZOLYLPYRIDINE PYRIDAZINONE AMIDE AS SOS1 INHIBITOR Cyrus Therapeutics Inc. (KR) 2025-12-24 EP disclosed
US-20250339402-A1 EFFECTIVE MEANS TO MODULATE NMDA RECEPTOR-MEDIATED TOXICITY FUNDAMENTAL PHARMA GMBH (DE) 2025-11-06 US disclosed
WO-2000066167-A1 CONTRACEPTIVE COMPOSITIONS CONTAINING INDOLINE DERIVATIVES AND PROGESTATIONAL AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-09 WO disclosed
WO-2000066556-A1 INDOLINE DERIVATIVES AS PROGESTERONE ANTAGONISTS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-09 WO disclosed
WO-2000066571-A1 CYCLOCARBAMATE DERIVATIVES AS PROGESTERONE RECEPTOR MODULATORS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-11-09 WO disclosed
US-5489592-A ALDOSE REDUCTASE INHIBITORS FOR TREATMENT OF DIABETES-RELATED DISORDERS LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) 1996-02-06 US disclosed
EP-0607344-A1 3,4-DIHYDRO-4-OXO-3-(PROP-2-ENYL)-1-PHTALAZINEACETIC ACIDS AND DERIVATIVES, PREPARATIONS THEREOF AND DRUGS CONTAINING SAME LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) 1994-07-27 EP disclosed
WO-1993007109-A1 3,4-DIHYDRO-4-OXO-3-(PROP-2-ENYL)-1-PHTALAZINEACETIC ACIDS AND DERIVATIVES, PREPARATIONS THEREOF AND DRUGS CONTAINING SAME LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) 1993-04-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250339402-A1 EFFECTIVE MEANS TO MODULATE NMDA RECEPTOR-MEDIATED TOXICITY TRPM4, GRM4, GRIN1 ERN1 3222/4885LMNA 4719/4885MEN1 1169/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.