Sugi Predict

Sugi Predict / Compounds / SCHEMBL223169

SCHEMBL223169

SCHEMBL223169

COC(=O)COc1ccc(N)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTGS2 P35354 2/20 0.57
▸ ALDH1A1 P00352 1/20 0.53
▸ CYP2C9 P11712 1/20 0.53
▸ CYP2C19 P33261 1/20 0.53
▸ MAPT P10636 2/20 0.51
▸ POLB P06746 2/20 0.50
▸ KMT2A Q03164 2/20 0.50
▸ L3MBTL1 Q9Y468 2/20 0.50
▸ MEN1 O00255 1/20 0.50
▸ TSHR P16473 1/20 0.50
▸ TDP1 Q9NUW8 1/20 0.50
▸ SYK P43405 1/20 0.49
▸ GAA P10253 3/20 0.49
▸ LMNA P02545 1/20 0.49
▸ GLA P06280 1/20 0.48
▸ PPARD Q03181 1/20 0.48
▸ NPC1 O15118 1/20 0.47
▸ TP53 P04637 1/20 0.47
▸ RAB9A P51151 1/20 0.47
▸ SMN1; SMN2 Q16637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7327250 0.98 PTGS2 (0.55) PTGS2ALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL3973631 0.95 PTGS2 (0.53) PTGS2ALDH1A1CYP2C9CYP2C19MAPT
Hydrochloric Acid SCHEMBL3973727 0.93 PTGS2 (0.51) PTGS2ALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL829458 0.93 PTGS2 (0.51) PTGS2ALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL2116437 0.90 PTGS2 (0.66) PTGS2ALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL13063409 0.87 PTGS2 (0.46) PTGS2ALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL831246 0.84 APP (0.49) PTGS2ALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL4670183 0.84 PTGS2 (0.50) PTGS2ALDH1A1KMT2AMEN1SYK
SCHEMBL12061812 0.84 GAA (0.66) PTGS2ALDH1A1CYP2C9CYP2C19MAPT
SCHEMBL17365269 0.84 PTGS2 (0.60) PTGS2ALDH1A1CYP2C9CYP2C19MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 284 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025067168-A1 AZA FUSED RING COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF 苏州爱科百发生物医药技术有限公司 2025-04-03 — — WO disclosed
US-12264169-B2 Heteroaryl inhibitors of PDE4 Tetra Discovery Partners (US) 2025-04-01 — — US disclosed
US-12110278-B2 Selective JAK2 pseudokinase ligands and methods of use YALE UNIVERSITY (US) 2024-10-08 — — US disclosed
US-20230348501-A1 HETEROARYL INHIBITORS OF PDE4 Tetra Discovery Partners, LLC 2023-11-02 — — US disclosed
US-20230314322-A1 SYSTEMS AND METHODS OF SEQUENCING POLYNUCLEOTIDES ILLUMINA, INC. 2023-10-05 — — US disclosed
WO-2023186819-A1 CHROMENOQUINOLINE DYES AND USES IN SEQUENCING ILLUMINA CAMBRIDGE LIMITED (GB) 2023-10-05 — — WO disclosed
US-20230313292-A1 CHROMENOQUINOLINE DYES AND USES IN SEQUENCING ILLUMINA, INC. 2023-10-05 — — US disclosed
US-11767334-B2 Heteroaryl inhibitors of PDE4 Tetra Discovery Partners, LLC (US) 2023-09-26 — — US disclosed
US-20230024240-A1 HETEROARYL INHIBITORS OF PDE4 Tetra Discovery Partners, LLC 2023-01-26 — — US disclosed
US-20220387602-A1 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE NOVARTIS AG (CH) 2022-12-08 — — US disclosed
EP-0718287-A2 Piperazine derivatives, medicaments containing them, their use, and processes for their preparation Dr. Karl Thomae GmbH (DE) 1996-06-26 — — EP disclosed
EP-0711768-A1 BENZIMIDAZOLE DERIVATIVE MITSUI TOATSU CHEMICALS, Inc. (JP) 1996-05-15 — — EP disclosed
EP-0691959-A1 HETEROCYCLIC DERIVATIVES AS PLATELET AGGREGATION INHIBITORS ZENECA LIMITED (GB) 1996-01-17 — — EP disclosed
EP-0690847-A1 HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS ZENECA LIMITED (GB) 1996-01-10 — — EP disclosed
EP-0676398-A2 Heterocyclic compounds having anti-diabetic activity, their preparation and their use SANKYO COMPANY LIMITED (JP) 1995-10-11 — — EP disclosed
WO-1995015952-A1 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS ZENECA LIMITED (GB) 1995-06-15 — — WO disclosed
EP-0632019-A1 Acylureas ZENECA LIMITED (GB) 1995-01-04 — — EP disclosed
WO-1994022835-A2 HETEROCYCLIC COMPOUNDS AS PLATELET AGGREGATION INHIBITORS ZENECA LIMITED (GB) 1994-10-13 — — WO disclosed
WO-1994022834-A1 HETEROCYCLIC DERIVATIVES AS PLATELET AGGREGATION INHIBITORS ZENECA LIMITED (GB) 1994-10-13 — — WO disclosed
US-4083844-A Phenylazo orthocyano phenylazo or orthocyano phenylazo phenylazo containing dyestuffs BAYER AKTIENGESELLSCHAFT (DT) 1978-04-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12110278-B2 Selective JAK2 pseudokinase ligands and methods of use JAK2, JAK1, MCL1 PTGS2 341/4885ALDH1A1 3690/4885CYP2C9 4279/4885
US-20230024240-A1 HETEROARYL INHIBITORS OF PDE4 PDE4A, PDE4B, PDE4C PTGS2 75/4885ALDH1A1 1152/4885CYP2C9 1536/4885
US-20220387602-A1 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE JMJD7, MDM2, IDE PTGS2 3555/4885ALDH1A1 2189/4885CYP2C9 2564/4885
US-20230348501-A1 HETEROARYL INHIBITORS OF PDE4 PDE4A, PDE4B, PDE4C PTGS2 75/4885ALDH1A1 1152/4885CYP2C9 1536/4885
US-11767334-B2 Heteroaryl inhibitors of PDE4 PDE4A, PDE4B, PDE4C PTGS2 75/4885ALDH1A1 1152/4885CYP2C9 1536/4885
US-12264169-B2 Heteroaryl inhibitors of PDE4 PDE4A, PDE4B, PDE4C PTGS2 75/4885ALDH1A1 1152/4885CYP2C9 1536/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.