Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 11/20 | 0.56 |
| ▸ | GSTA1 | P08263 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.56 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.56 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.56 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.56 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10659730 | 0.88 | GSTP1 (0.52) | GSTP1GSTA1ALDH1A1LMNAMEN1 | |
| SCHEMBL13284005 | 0.88 | GSTP1 (0.70) | GSTP1GSTA1ALDH1A1LMNAMEN1 | |
| SCHEMBL11656296 | 0.85 | GSTP1 (0.52) | GSTP1GSTA1ALDH1A1LMNAMEN1 | |
| SCHEMBL10001217 | 0.83 | GSTP1 (0.81) | GSTP1GSTA1ALDH1A1LMNAMEN1 | |
| SCHEMBL11603324 | 0.81 | THRB (0.52) | GSTP1GSTA1ALDH1A1LMNAMEN1 | |
| SCHEMBL9717498 | 0.81 | GSTP1 (0.62) | GSTP1GSTA1ALDH1A1LMNAMEN1 | |
| SCHEMBL10678567 | 0.80 | GSTP1 (0.51) | GSTP1GSTA1ALDH1A1LMNAMEN1 | |
| SCHEMBL11451833 | 0.80 | GSTP1 (0.48) | GSTP1GSTA1ALDH1A1LMNAMEN1 | |
| SCHEMBL9717542 | 0.79 | GSTP1 (0.53) | GSTP1GSTA1ALDH1A1LMNAMEN1 | |
| SCHEMBL9717561 | 0.78 | GSTP1 (0.48) | GSTP1GSTA1ALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11000492-B2 | Fluorenone compound for the treatment of gout | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-05-11 | — | — | US | disclosed |
| US-20200246289-A1 | FLUORENONE COMPOUND FOR THE TREATMENT OF GOUT | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11000492-B2 | Fluorenone compound for the treatment of gout | SLC10A1, PCSK9, PCSK7 | GSTP1 1344/4885GSTA1 826/4885ALDH1A1 1105/4885 |
| US-20200246289-A1 | FLUORENONE COMPOUND FOR THE TREATMENT OF GOUT | SLC10A1, PCSK9, PCSK7 | GSTP1 1344/4885GSTA1 826/4885ALDH1A1 1105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.