Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSTP1 | P09211 | 13/20 | 0.52 |
| ▸ | GSTA1 | P08263 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.52 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.52 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.52 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.52 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11656296 | 0.90 | GSTP1 (0.52) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL22317249 | 0.88 | GSTP1 (0.56) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL13284005 | 0.85 | GSTP1 (0.70) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL11451833 | 0.80 | GSTP1 (0.48) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL11655793 | 0.76 | GSTP1 (0.45) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL10657187 | 0.76 | THRB (0.50) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL11660810 | 0.75 | ALDH1A1 (0.43) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL11660813 | 0.75 | ALDH1A1 (0.43) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL10657116 | 0.75 | THRB (0.49) | GSTP1GSTA1MEN1ABCC3PLIN1 | |
| SCHEMBL8986308 | 0.74 | GSTP1 (0.71) | GSTP1GSTA1MEN1ABCC3PLIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4731471-A | (5,6-dichloro-3-oxo-2,3,9,9a-tetrahydrofluoren-7-yl)-alkanoic acids and alkanimidamides bearing novel functional 9a-substituents | MERCK & CO., INC. (US) | 1988-03-15 | — | — | US | disclosed |
| US-4731470-A | BRAIN INJURY PREVENTION AND TREATMENT | MERCK & CO., INC. (US) | 1988-03-15 | — | — | US | disclosed |