SCHEMBL22319399

SCHEMBL22319399

COC(=O)c1cc(-c2ccccc2)ccc1Oc1ccc(F)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC6A4 P31645 2/20 0.52
▸ SLC6A3 Q01959 1/20 0.52
▸ FPR2 P25090 1/20 0.52
▸ SCN9A Q15858 1/20 0.52
▸ HTR2A P28223 1/20 0.51
▸ PLA2G2A P14555 1/20 0.46
▸ NR4A2 P43354 2/20 0.46
▸ KDM4E B2RXH2 2/20 0.46
▸ ALDH1A1 P00352 1/20 0.46
▸ CYP1A2 P05177 1/20 0.46
▸ HPGD P15428 1/20 0.46
▸ CHRNA7 P36544 1/20 0.46
▸ DHODH Q02127 1/20 0.46
▸ ACLY P53396 1/20 0.45
▸ HSD17B10 Q99714 1/20 0.44
▸ PNLIP P16233 1/20 0.44
▸ MET P08581 1/20 0.43
▸ MEN1 O00255 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ EGFR P00533 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31028179 0.86 MIF (0.51) SLC6A4HTR2AKDM4EDHODHACLY
SCHEMBL22319398 0.86 MIF (0.51) SLC6A4HTR2AKDM4EDHODHACLY
SCHEMBL30974578 0.86 KDM4E (0.46) SLC6A4SLC6A3HTR2ANR4A2KDM4E
SCHEMBL29250437 0.86 KDM4E (0.46) SLC6A4SLC6A3HTR2ANR4A2KDM4E
SCHEMBL29250430 0.85 SCN8A (0.54) SLC6A4SLC6A3HTR2APLA2G2AKDM4E
SCHEMBL11421571 0.84 SLC6A3 (0.55) SLC6A4SLC6A3MEN1KMT2A
SCHEMBL27850308 0.83 SLC6A3 (0.64) SLC6A4SLC6A3KDM4EALDH1A1CYP1A2
SCHEMBL21359481 0.83 SLC6A3 (0.52) SLC6A4SLC6A3PLA2G2ANR4A2KDM4E
SCHEMBL22319382 0.82 PTGER4 (0.66) ALDH1A1HPGDMEN1KMT2APTGER4
SCHEMBL22861238 0.82 ROCK2 (0.52) SLC6A4SLC6A3FPR2SCN9APLA2G2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3921310-B1 NEW N-BENZYL-2-PHENOXYBENZAMIDE DERIVATIVES AS PROSTAGLANDIN E2 (PGE2) RECEPTORS MODULATORS MEDIBIOFARMA S L (ES) 2026-01-14 — — EP disclosed
CN-113646299-B Novel N-benzyl-2-phenoxybenzamide derivatives as prostaglandin E2 (PGE 2) receptor modulators 梅迪比奥法尔玛公司 2024-07-26 — — CN disclosed
US-11872226-B2 N-benzyl-2-phenoxybenzamide derivatives as prostaglandin E2 (PGE2) receptors modulators MEDIBIOFARMA, S.L. (ES) 2024-01-16 — — US disclosed
US-20220117962-A1 NEW N-BENZYL-2-PHENOXYBENZAMIDE DERIVATIVES AS PROSTAGLANDIN E2 (PGE2) RECEPTORS MODULATORS MEDIBIOFARMA, S.L. (ES) 2022-04-21 — — US disclosed
CN-113646299-A Novel N-benzyl-2-phenoxybenzamide derivatives as prostaglandin E2(PGE2) receptor modulators 梅迪比奥法尔玛公司 2021-11-12 — — CN disclosed
EP-3693359-A1 NEW N-BENZYL-2-PHENOXYBENZAMIDE DERIVATIVES AS PROSTAGLANDIN E2 (PGE2) RECEPTORS MODULATORS MEDIBIOFARMA, S.L. (ES) 2020-08-12 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220117962-A1 NEW N-BENZYL-2-PHENOXYBENZAMIDE DERIVATIVES AS PROSTAGLANDIN E2 (PGE2) RECEPTORS MODULATORS PTGER2, PTGER4, PTGER1 SLC6A4 1933/4885SLC6A3 3381/4885FPR2 83/4885
US-11872226-B2 N-benzyl-2-phenoxybenzamide derivatives as prostaglandin E2 (PGE2) receptors modulators PTGER2, PTGER4, PTGER1 SLC6A4 2091/4885SLC6A3 3334/4885FPR2 73/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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