SCHEMBL22320323

SCHEMBL22320323

COCOc1ccc(C(C)(C)c2ccccc2)cc1C(C)(C)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.41
ALDH1A1 P00352 5/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
LMNA P02545 2/20 0.41
MEN1 O00255 6/20 0.40
KMT2A Q03164 6/20 0.40
ESR1 P03372 2/20 0.40
ESR2 Q92731 2/20 0.40
CYP3A4 P08684 1/20 0.40
POLB P06746 2/20 0.36
CNR1 P21554 2/20 0.35
CNR2 P34972 2/20 0.35
HTT P42858 2/20 0.35
EGFR P00533 2/20 0.35
NR3C2 P08235 1/20 0.35
MITF O75030 1/20 0.34
MAPT P10636 1/20 0.34
MAPK1 P28482 1/20 0.34
UBE2N P61088 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30619650 1.00 KDM4E (0.41) KDM4EALDH1A1SMN1; SMN2LMNAMEN1
SCHEMBL14560668 0.82 ALDH1A1 (0.46) KDM4EALDH1A1SMN1; SMN2LMNAMEN1
SCHEMBL21606173 0.81 ALDH1A1 (0.44) KDM4EALDH1A1SMN1; SMN2LMNAMEN1
SCHEMBL28611764 0.80 ALDH1A1 (0.47) KDM4EALDH1A1SMN1; SMN2LMNAMEN1
SCHEMBL30545318 0.80 ESR1 (0.47) KDM4EALDH1A1SMN1; SMN2LMNAMEN1
SCHEMBL9502507 0.79 KDM4E (0.39) KDM4EALDH1A1SMN1; SMN2LMNAMEN1
SCHEMBL9502525 0.79 PTGDR2 (0.52) KDM4EALDH1A1SMN1; SMN2LMNAMEN1
SCHEMBL15423891 0.79 ALDH1A1 (0.46) KDM4EALDH1A1SMN1; SMN2LMNAMEN1
SCHEMBL12084721 0.79 ALDH1A1 (0.40) KDM4EALDH1A1SMN1; SMN2LMNAMEN1
SCHEMBL2240319 0.78 ALDH1A1 (0.40) KDM4EALDH1A1SMN1; SMN2LMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230348634-A1 Propylene Polymers Obtained Using Transition Metal Bis(Phenolate) Catalyst Complexes and Homogeneous Process for Production Thereof EXXONMOBIL CHEMICAL PATENTS INC (US) 2023-11-02 US disclosed
US-20230348634-A1 Propylene Polymers Obtained Using Transition Metal Bis(Phenolate) Catalyst Complexes and Homogeneous Process for Production Thereof EXXONMOBIL CHEMICAL PATENTS INC (US) 2023-11-02 US disclosed
US-20230348634-A1 Propylene Polymers Obtained Using Transition Metal Bis(Phenolate) Catalyst Complexes and Homogeneous Process for Production Thereof EXXONMOBIL CHEMICAL PATENTS INC (US) 2023-11-02 US disclosed
EP-3924395-A1 B!S(ARYL PHENOLATE) LEWIS BASE CATALYSTS AND METHODS THEREOF ExxonMobil Chemical Patents Inc. (US) 2021-12-22 EP disclosed
US-11203654-B2 Bis(aryl phenolate) lewis base catalysts and methods thereof EXXONMOBIL CHEMICAL PATENTS INC. (US) 2021-12-21 US disclosed
US-11203654-B2 Bis(aryl phenolate) lewis base catalysts and methods thereof EXXONMOBIL CHEMICAL PATENTS INC. (US) 2021-12-21 US disclosed
WO-2021162746-A1 PROPYLENE POLYMERS OBTAINED USING TRANSITION METAL BIS(PHENOLATE) CATALYST COMPLEXES AND HOMOGENEOUS PROCESS FOR PRODUCTION THEREOF EXXONMOBIL CHEMICAL PATENTS INC. (US) 2021-08-19 WO disclosed
WO-2020167824-A1 B!S(ARYL PHENOLATE) LEWIS BASE CATALYSTS AND METHODS THEREOF EXXONMOBIL CHEMICAL PATENTS INC. (US) 2020-08-20 WO disclosed
WO-2020167824-A1 B!S(ARYL PHENOLATE) LEWIS BASE CATALYSTS AND METHODS THEREOF EXXONMOBIL CHEMICAL PATENTS INC. (US) 2020-08-20 WO disclosed
US-20200254431-A1 BIS(ARYL PHENOLATE) LEWIS BASE CATALYSTS AND METHODS THEREOF EXXONMOBIL CHEMICAL PATENTS INC. 2020-08-13 US disclosed
US-20200254431-A1 BIS(ARYL PHENOLATE) LEWIS BASE CATALYSTS AND METHODS THEREOF EXXONMOBIL CHEMICAL PATENTS INC. 2020-08-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11203654-B2 Bis(aryl phenolate) lewis base catalysts and methods thereof PHKB, TYR, ELL KDM4E 928/4885ALDH1A1 1743/4885SMN1; SMN2 3843/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.