Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2143714 | 0.85 | POLB (0.56) | ALDH1A1EGLN1ALOX15LMNAL3MBTL1 | |
| SCHEMBL2143791 | 0.84 | POLB (0.53) | ALDH1A1LMNAHSD17B10L3MBTL1SMN1; SMN2 | |
| SCHEMBL2143854 | 0.83 | ALDH1A1 (0.49) | ALDH1A1EGLN1L3MBTL1POLBGPBAR1 | |
| SCHEMBL2143749 | 0.78 | ALDH1A1 (0.57) | ALDH1A1EGLN1ALOX15LMNATP53 | |
| SCHEMBL2143986 | 0.77 | ALDH1A1 (0.47) | ALDH1A1EGLN1PRMT5WDR77SMN1; SMN2 | |
| SCHEMBL2143814 | 0.74 | SLC22A12 (0.52) | ALDH1A1EGLN1L3MBTL1PRMT5WDR77 | |
| SCHEMBL2143801 | 0.74 | ALDH1A1 (0.47) | ALDH1A1EGLN1PRMT5WDR77GPBAR1 | |
| SCHEMBL2143724 | 0.74 | ALDH1A1 (0.58) | ALDH1A1EGLN1HSD17B10PRMT5WDR77 | |
| SCHEMBL2143848 | 0.73 | PDK1 (0.53) | ALDH1A1EGLN1GPBAR1 | |
| SCHEMBL2143822 | 0.73 | PDK1 (0.59) | ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | Polichem SA (LU) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080264-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM S.A. (LU) | 2011-07-07 | — | — | WO | disclosed |